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New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
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Games Available at GGBET’S New Online Casino
GGBET has recently launched its new online casino, introducing a refreshing platform for gaming enthusiasts. This new venture promises a wide array of games, catering to multiple tastes and preferences. From the classic slot Legacy of Egypt to table titles and live dealer experiences, GGBET aims to provide a comprehensive gambling experience. In this article, we’ll
explore the various types of games available at the platform, highlighting what makes each category unique. Whether you’re a new or seasoned player, there’s something for everyone!
First Look at GGBET Novel Casino
From your first visit to the site, you can see that the platform was designed with user experience in mind. The sleek, modern interface ensures easy navigation, allowing players to quickly find their favourite titles. It’s fully secure, with a license from the UK Gambling Commission (UKGC). With generous bonuses and promotions to claim after registration, every player can feel welcomed and valued from the moment they join.
Types of Titles on Offer at the Casino
After easing security concerns, the priority for any casino is to offer a portfolio that’ll appeal to multiple player types. GGBET excels in this arena, working with the industry’s best developers to supply a consistent stream of high-quality games. Check out the various categories of titles you’ll find!
Slots
Slots are a staple in any casino, and GGBET supersedes our expectations in this area. It offers an extensive collection of 2,000 slot titles from over 40 reputable providers. Members here can enjoy a variety of themes and gameplay styles, from classic three-reel machines to the latest video slots. Popular titles in this lobby include Legacy of Egypt, Hell Hot 100, and Demi Gods V.
What’s more? Slots here boast innovative in-game mechanics, such as expanding symbols, cascading reels, and multipliers. Each feature adds to the excitement and increases your winning potential. Whether you prefer high-volatility titles with big jackpots or low-volatility options with frequent wins, there are countless titles to explore. The platform also regularly
updates its library with new releases, so there are fresh and exciting games always.
Table Games
These refer to a group of games that involve strategy and pit you against others. The most popular examples are blackjack, roulette, and baccarat, all of which we’ve examined below.
● Blackjack: Are you a casual or high roller? The GGBET collection will suit your style. The thrill of the game lies in the simple decision-making process: hit, stand, double down, or split. Each choice can bring you closer to the coveted 21.
● Roulette: Roulette is a game that builds anticipation as the wheel spins. At GGBET, you can enjoy European and American versions and adjust your stakes according to the odds. We love this title due to the variety of bets you can place, from single numbers to red or black, odd or even.
● Baccarat: This is a simple title where the dealer does all the work, drawing cards according to rules, while you sit back and enjoy the gameplay. Your choices are straightforward: bet on the banker, the player, or a tie. Variants you’ll find at this platform include Bunco Banco, Chemin de Fer, and Speed.
Live Casino
The GGBET live casino section is where the line between reality and virtual blurs. Imagine the thrill of a bustling casino floor, now accessible from your living room. These games aren’t just about playing; they’re about experiencing. With high-definition streaming and multiple camera angles, you get a front-row seat to every shuffle, spin, and deal.
The real magic happens with the live dealers, who are more than just facilitators. They guide you through the whole experience to ensure a seamless affair. Thanks to the live chat, you can share a conversation with them or other players.
In addition to standard categories like roulette, blackjack, and baccarat, GGBET introduces innovative game formats like Crazy Time and Monopoly Live. These titles mix traditional casino elements with game show excitement, keeping you on the edge of your seat.
Everyone Is Welcome at GGBET New Casino
By stocking a diverse cast of games, GGBET escapes the trap many new casinos fall for. The platform ensures that all players can have fun here, notwithstanding their preferences. That, too, while offering a user-friendly interface that enables seamless gaming. Throw in the promotions and an easy sign-up process, and you have one of the most solid new casinos we’ve ever seen.
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How technological growth has influenced sports betting
The sports betting industry has experienced some major changes over the past few years and a lot of that has been due to amazing advances in technology. Players have a range of new ways to wager that also allow them to access more sports betting platforms than ever before. In this article, we’ll explore the effects of technological growth on sports betting, ranging from online platforms and mobile accessibility to data use and livestreaming technology. We’ll also touch on what else could be in store for the future in this rapidly changing industry.
The evolution of online sports betting
In the past, sports betting usually took place in physical casinos, but this all changed in the 90s when the internet became popular and online betting platforms started to take off. Suddenly, it was possible for Canadian sports fans to bet from the comfort of their own homes. Since then, sportsbooks have continued to evolve to provide personalized experiences with a wider variety of betting options.
Today, Canadian players have access to a range of betting sites that specifically cater to the Canadian market that include features that meet local preferences while still sticking to the necessary regulatory requirements needed to stay compliant. This has resulted in a much safer and more convenient environment for players to enjoy sports betting.
Mobile technology and betting on the go
The biggest impact to sports betting has been the growth of mobile technology as the wide adoption of smartphones and tablets has made it possible to place bets anytime and anywhere. Mobile-optimized sportsbooks and customized betting apps have changed the way sports fans interact with betting platforms. It has allowed users to take part in live betting and check the odds in real time for instant updates. Some platforms even have notification and game result pop ups so there’s no need for players to ever miss out on the action.
The increased use of live betting
One of the most popular features of online sportsbooks is live betting. This type of betting allows players to place wagers during a live game or event. Data is processed quickly and analytics are used in real time to update the odds as the game progresses, which allows bettors to make more informed decisions.
For instance, during a hockey game, players can bet on which team they think will score the next goal and they can try and predict how many goals there will be during the game. This type of live, interactive betting can create an exciting atmosphere for sports fans who are eager to see if their predictions come true.
Analytics and big data in online sports betting
Big data has enhanced sports betting by giving players detailed insight on sports teams and their overall game dynamics. This is done using advanced tools, in which data analytics gather and analyze past performances, injury reports and other types of player statistics in order to predict outcomes. This information is valuable as it gives players access to more precise odds and provides a greater sense of transparency.
Artificial intelligence and personalization
Artificial intelligence (AI) has raised the bar for sports betting as AI algorithms can detect patterns in player behaviour and uses their betting habits to create a personalized experience. As a result, bettors are offered recommendations and tailor-made promotions based on their past betting history.
AI can also help with responsible gambling by spotting any potential gambling issues. It can trigger alerts and notifications to help users get back on track if needed.
Blockchain and cryptocurrency
In recent years, we’ve seen an increase in the use of cryptocurrency in the online betting world. As technology advances, it’s believed that cryptocurrencies like Bitcoin could become a common currency used in the future of sports betting. This will offer Canadian players a wider range of payment method options. Cryptocurrency can offer many benefits as it uses blockchain technology to make transactions faster and more secure. Cryptocurrency often has lower fees when compared to
traditional payment methods.
Enhanced security measures
Technological growth in the sports betting industry has made safety and responsible gambling more of a priority than ever. Canadian platforms are now applying robust security features like two-factor authentication and advanced encryption that protect users’ personal data and financial information.
Promoting responsible sports betting
Sportsbooks now offer numerous tools to encourage responsible gambling such as setting deposit limits, taking time out for breaks and self-exclusion options. As the industry grows, Canadian gambling regulators will continue to make sure that sports bettors have access to secure and fair betting platforms at all times.
If you are struggling with controlling your gambling, there are many responsible gambling organizations that can help. Be sure to reach out for assistance.
The future of technology in sports betting
The future of sports betting in Canada will likely continue to be influenced by advancing technology, and the development of 5G networks should make mobile and live betting faster and more reliable than ever before.
Further down the road, we expect to see virtual reality and augmented reality incorporated in sports betting, so fans can immerse themselves in a virtual world and feel like they’re in a stadium or arena, which is perfect for those who aren’t able to attend games in person.
Overall, technological advances have made sports betting more accessible, engaging and personalized, to suit individual preferences for a truly modern and interactive betting experience.
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