Also Interesting
New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
Also Interesting
Patterns of Play in Québec: How Smartphones Are Powering Online Casino Growth
Mobile has become the default screen for entertainment in Québec, from streaming to short-form video to bite-sized gaming. When I look at how people actually spend their downtime, it’s clear that the phone wins because it fits around life—on the metro, in a coffee line, or on the couch while a show runs in the background. In this post, I’ll break down why mobile-first habits are accelerating online casino growth, the features that keep players returning to their phones, and the practical settings that make play smoother and more intentional.
Why Québec Is Moving to the Small Screen
Phones shape behavior through short, repeatable “micro-sessions.” A spare two minutes turns into a quick spin, a side quest, or a daily check-in reward. This rhythm aligns with broader Canadian trends: internet and mobile use remain near-universal, and social-style engagement has trained us to prefer fast, thumb-driven loops. Reports tracking Canada’s digital life show high penetration of mobile connections and heavy social usage—both predictors of strong mobile gaming engagement.
Design also matters. Modern casino apps and mobile sites lift cues from social feeds—persistent nav bars, swipeable cards, haptic taps, and instant feedback. The result is a UX that feels familiar even if the game is new. Hybrid monetization (in-app purchases alongside ad-supported rewards or subscriptions) also keeps the experience flexible for different budgets and play styles.
Signals From the Gaming and Payments Ecosystem
Canadian gamers are increasingly incorporating mobile devices into their weekly routines. Recent coverage notes that a substantial majority of players use smartphones weekly for gaming, reflecting the convenience of pick-up-and-play formats. That preference supports casino-style content, where quick sessions and event-driven bonuses are efficient.
Payments are evolving alongside play. The latest national payments research highlights steady growth in digital methods and mobile-friendly transactions, with tap-and-go habits extending to in-app expectations. For players, this translates into faster top-ups, robust device security options (such as biometrics), and fewer abandoned deposits.
The Mobile UX That Keeps Players Engaged
Excellent mobile casino experiences share a few traits. First, they compress decisions: big buttons, readable odds and win potential, and minimal required text. Second, they personalize quickly—surfacing “recently played,” daily streaks, or seasonal events up top. Third, they respect session length, offering fast load times, one-handed play, and clear exit points, so it’s easy to stop when you planned to.
From my own testing and reviews, the stickiest flows do three simple things well:
- Surface momentum: Onboarding ends with a playable moment rather than a dead-end settings screen.
- Simplify payments: Wallets remember preferred methods and confirm with Face ID or fingerprint.
- Reward cadence: Progress bars, level-ups, and time-limited events make short sessions feel meaningful.
A Quick, Local Guide for New and Returning Players
If you’re exploring mobile options and want a single page that maps the landscape for Québec readers, start with a detailed guide to online casinos in Québec—it’s a straightforward overview of platforms, banking, and play considerations. The resource provides tools and comparisons that many readers find helpful, and it originates from Gambling Nerd Canada, a brand known for its practical breakdowns rather than hype.
Privacy, Performance, and Control on Your Phone
Before a long session, think like a power user. Turn on low-power mode, reduce background refresh for nonessentials, and enable biometric locks for your wallet app. Use notification summaries so bonuses and reminders arrive on your schedule, not in scattered pings throughout the day. If privacy is top of mind, note the broader consumer shift toward privacy-aware browsing and app choices—an indicator that many users want speed without sacrificing control.
Practical Settings I Recommend
Start with a one-time setup and revisit monthly:
- Biometric approvals: Fingerprint or Face ID for payments and account access.
- Focus modes: A “Play” focus that mutes noncritical apps prevents distraction.
- Data caps and Wi-Fi assist: Ensure stable play when switching networks.
- Notification batching: Keep promotional pings contained to a scheduled summary.
- Accessibility tweaks: Larger text and stronger contrast reduce mis-taps in fast games.
What’s New in 2026: Features to Watch
Mobile gaming in 2026 is doubling down on personalization and live-service content. Think dynamic events, social play hubs, and cross-platform syncing so you can pick up progress anywhere. Industry tracking points to hybrid monetization and more innovative analytics guiding these updates, which typically means more tailored offers and seasonal content drops. For players, the upshot is fresher content and smoother progression across short sessions.
Québec’s mobile-first reality isn’t about bigger screens or faster chips—it’s about how phones fit our days. Short, satisfying sessions, fluid payments, and personalized content make the experience feel effortless. If you dial in a few device settings and use trusted resources to compare options, you’ll get the convenience you want without the clutter you don’t.
Also Interesting
When Chats Drag On for Months and Go Nowhere – And What to Do About It
We’ve all had that one chat: lots of jokes, some flirting, maybe even deep talks… and yet you never actually meet. Or call. Or do anything.
It feels like something, but also like nothing. Let’s gently call it what it is: a situationship in your phone.
Why We Get Stuck in Endless Chatting
Some common reasons:
● Fear of rejection if you move it offline.
● It’s a comforting distraction when you’re lonely or stressed.
● You’re both busy and don’t want to prioritize each other yet.
● One or both of you like the ego boost more than the person.
Here’s a quick pattern table:
Pattern What’s usually going on
Lots of texting, no concrete plans Avoidance or low real-life interest
Strong flirting, zero follow-through Validation more than true intention
“We should meet sometime” on repeat Vague comfort zone, not real action
How Long Is “Too Long” Without Meeting?
There’s no exact rule, but for most people:
● 1–2 weeks of active texting → reasonable to suggest a call or date.
● 4+ weeks of frequent texting, zero effort to meet → something’s off.
If your “relationship” is starting to feel like a pen pal romance, it’s time to shift.
How to Move Things Forward (or End It)
You can keep it very simple:
● “I’m enjoying chatting with you. Want to grab a coffee next week and see how this feels offline?”
● “I’m not great at endless texting — would you be up for a quick video call sometime via online dating for singles?”
If they dodge vague excuses again and again, you have your answer.
Giving Yourself Permission to Let It Go
Ending a long chat connection can feel weirdly like a breakup, even if you never met. It’s still emotional energy.
You can say:
● “I’ve appreciated our chats, but I’m looking for something that can move into real life. I’m going to step back from this.”
Then mute, archive, or delete. And yes, you’re allowed to feel a bit sad and still know it was the right call.
Your Time Is Valuable
At the end of the day, your dating life is part of your actual life, not a separate mini-game.
You deserve:
● Conversations that lead somewhere
● Dates that feel safe, curious, and real
● Relationships (or explorationships) that respect your energy
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