Also Interesting
New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
Also Interesting
How Australians Lose Thousands Each Year on Gaming and Gambling Mistakes
7 Everyday Money Mistakes Aussie Players Make in 2025
Every punter reckons they’ve got their spending under control until the bank app shows a very different story. From late-night spins to $150 skin drops in Fortnite, the little “harmless” hits add up stupidly fast. Anyone wanting the real picture on where the dollars actually disappear should bookmark https://onlinecasino-in-australia.com/ – it breaks down the maths behind every bonus and withdrawal so nothing is left to guesswork.
1. Chasing Losses After a Bad Session
Classic rookie move. Drop $200 on a cold night and immediately fire another $300 trying to get even. Next morning the account is $500 lighter and the mood is cooked.
2. Buying V-Bucks, Apex Coins or FIFA Points on Impulse
A new Battle Pass drops, the mates are all grabbing the shiny skin, and suddenly $79.95 is gone for something that literally vanishes when the season ends. In 2025 the average 18–34-year-old spends $420 a year on console/PC cosmetics that have zero resale value. That same cash parked in an ING saver would be $450 with interest by Christmas.
3. Ignoring Bonus Wagering Requirements
Grab a fat welcome offer from an online casino Australia without reading the fine print and the “free” $500 is locked behind 40× wagering. End up grinding an extra $20 000 in turnover just to unlock $180 profit. Painful.
4. Using Credit or Afterpay for Gambling Deposits
Some punters still slap $500 on the credit card “because the bonus is huge”. Interest at 22 % kicks in the second the statement drops. One bad month and the win gets eaten by fees.
5. Reversing Withdrawals at 2 a.m.
Win $800, hit withdraw, then see the “reverse” button glowing while the pending period ticks. Ninety percent of reversed withdrawals are lost. Easy withdrawal online casino Australia sites that pay instantly (PayID, crypto) remove that temptation completely.
6. Paying for “Pro” Subscriptions in Mobile Games
Candy Crush extra lives, Raid Shadow Legends monthly pack, Genshin Welkin Moon – looks cheap at $8 a month but stacks to $100+ a year for zero lasting value. Most players quit the game inside six months anyway.
7. Not Shopping Around for the Best Platform
Loyalty to one site is cute until the next place is running 200 free spins + 20 % cashback while the usual joint offers nothing. The best online casino in Australia changes weekly – checking fresh deals takes two minutes and saves hundreds.
Quick 2025 Cost-of-mistakes Table (Average Punter)
Most punters think the damage is “just a couple of hundred here and there” until you actually add it up for the full year. Here’s what the typical 18–35-year-old is quietly torching on completely avoidable stuff. The numbers are conservative – plenty blow way past the top end.
| Money mistake | Yearly cost (AUD) |
| Impulse cosmetics & battle passes | $350–$600 |
| Chasing losses (just twice a year) | $800–$2 000 |
| Reversed withdrawals | $500–$1 500 |
| Credit-card interest on deposits | $200–$800 |
| Missing better bonuses elsewhere | $300–$700 |
| Total damage | $2 150–$5 600 |
That’s a bloody house deposit chunk disappearing on pure avoidable stuff.
How to flip the script instead
The good news is every single one of those money leaks can be shut off in about five minutes flat. A handful of dead-simple rules turn the same hobbies from budget killers into something that’s either neutral or quietly profitable. Here’s the playbook the smart punters are already running:
- Treat gaming and gambling money like any other entertainment budget – $50–$100 a week max, prepaid
- Only play with profit or bonuses at an online casino Australia real money site
- Skip every cosmetic that costs more than a schooner – if it’s not on special, it’s not worth it
- Use fast withdrawal online casino Australia options, so wins hit the bank before the brain talks itself out of it
- Set “profit lock” rules: 50 % of every win goes straight to savings or bills
Do that and the same hobby that used to leak cash suddenly becomes neutral or even positive. Australia online casino players who stick to the rules above routinely bank $1k–$4k profit a year while the console crowd wonders where their paycheck went.
Bottom line
2025 is brutal on sloppy spending. Whether it’s a $150 Valorant bundle or a 3 a.m. revenge deposit, the mistakes all look small in the moment and massive by Christmas. Fix the seven leaks above and the average punter instantly keeps an extra two or three grand in their pocket without giving up the fun. Deadset life-changing.
Also Interesting
When Betting Became Part of Everyday Sports Culture
Online betting has expanded quietly into everyday life, shaped by sport, technology, and shifting habits rather than high-stakes ambition. As platforms become simpler and information more accessible, casual participation now defines much of the market. Understanding how and why this change happened helps explain what betting looks like today.
Online betting no longer lives on the fringes of sports fandom or late-night casino culture. Over the past decade, it has moved steadily into the mainstream, shaped by mobile technology, wider legal access, and a growing expectation that betting should be easy to understand rather than intimidating. For everyday players, that shift has changed what participation looks like. Betting today is less about high stakes and specialist knowledge and more about convenience, occasional engagement, and informed choice. Whether you are placing a small wager on a major sporting event or exploring digital slot games out of curiosity, the expansion of online betting reflects a broader change in how entertainment, sport, and digital platforms now intersect in daily life.
The Digital Expansion of Online Betting for Everyday Players
The most visible change in online betting has been how accessible it has become to people who would never have considered themselves regular gamblers. What was once dominated by complex interfaces and insider terminology is now designed around casual use, mobile screens, and short attention spans. That evolution has lowered the barrier to entry, allowing everyday players to explore betting environments without committing money upfront or learning everything at once.
A major part of that shift is the rise of informational platforms that focus on education and free-to-play experiences rather than direct wagering. Sites such as VegasSlotsOnline.com illustrate how the betting ecosystem has broadened beyond operators alone. Instead of pushing users straight toward real-money play, these platforms offer free slot demos, basic game explanations, and comparisons that help players understand how online casinos work before deciding whether to participate financially. That model aligns closely with how modern players behave, sampling first and committing later, if at all.
This approach reflects wider market data. Research from Grand View Research shows that online gambling growth is increasingly driven by casual and mobile users rather than high-frequency bettors, with convenience and accessibility cited as key factors behind continued expansion. For everyday players, the digital expansion of online betting is less about chasing big wins and more about having the option to engage on their own terms, at their own pace, with clearer information guiding those choices.

Sports Culture Still Drives Betting Interest at the Local Level
Despite the growth of digital betting platforms, the underlying engine remains unchanged. People bet because they care about sport. That connection still begins locally, shaped by teams, rivalries, and shared moments that stretch well beyond screens and apps. For everyday players, betting often feels like an extension of following sport rather than a separate activity.
In Canada, that cultural grounding is easy to see. Major leagues such as the NHL, CFL, NBA, and MLS continue to anchor sports attention, while local recognition still matters just as much. Events like the Alberta Sports Hall of Fame’s newly announced Class of 2026 inductees reflect how deeply sport remains woven into community identity. These ceremonies celebrate athletes and builders whose careers predate online betting entirely, yet their legacy still fuels the interest that modern betting platforms rely on.
Market data reinforces that link. Grand View Research notes that sports betting remains the largest revenue segment within Canada’s online gambling market, driven by major sporting events and seasonal competition cycles. When playoff races heat up or national teams take the spotlight, betting participation rises alongside viewership. For you as a casual participant, that means betting activity often follows the sports calendar you already care about. The expansion of online betting has not replaced traditional fandom; it has simply attached itself to it, riding on the same emotional investment that has always drawn people to sport.
Market Growth and Player Behaviour Behind the Numbers
The expansion of online betting is not anecdotal. It is backed by sustained market growth that helps explain why betting platforms have become more visible in everyday digital life. Globally, the online gambling market was valued at roughly $78.7 billion in 2024 and is projected to reach more than $150 billion by 2030, driven by double-digit annual growth. Canada mirrors that trajectory. The country’s online gambling market generated close to $4 billion in revenue in 2024 and is expected to more than double by the end of the decade, reflecting rising participation across sports betting and online casino segments.
What matters for everyday players is where that growth comes from. The fastest-growing segment is not high-stakes betting but casual, mobile-first participation. Smartphones now account for the majority of online betting activity, allowing users to place smaller, more frequent wagers tied to specific events rather than sustained sessions. Sports betting remains the largest revenue contributor in Canada, but online casino games, particularly slots, continue to grow as low-commitment entertainment options.
Player behaviour has shifted alongside these numbers. Market analysis shows that convenience, ease of use, and flexible participation drive engagement more than bonus size or betting complexity. Many users log in around major sporting events, place modest bets, then disengage until the next occasion. This pattern helps explain why online betting keeps expanding without relying solely on heavy users. For you, the numbers reveal a simple reality: the modern betting market is increasingly built around occasional participation, shaped by everyday habits rather than specialist gambling behaviour.

What Online Betting Looks Like for Casual Players Today
For most people, online betting no longer resembles the high-intensity, high-stakes activity it was once associated with. Today’s everyday players tend to engage sporadically, often around specific moments rather than as a routine habit. A major football final, a playoff series, or a marquee boxing match is far more likely to trigger participation than a random midweek fixture. That shift toward event-driven betting has reshaped how platforms are designed and how players interact with them.
Market data supports this behavioural change. Studies tracking user activity show that a large share of online bettors place low-value wagers and limit their sessions to short time windows, especially on mobile devices. Smartphones now account for the majority of online betting traffic, making it easier to place a quick bet without extended commitment. For you, that means betting fits around existing routines instead of demanding focused attention or long sessions.
Another defining feature is the preference for simplicity. Casual players gravitate toward straightforward bets and familiar formats rather than complex combinations. Moneyline bets, basic spreads, and simple slot games dominate usage, while more intricate options tend to appeal to a smaller subset of experienced users. This pattern reflects a broader trend across digital entertainment, where ease of access often outweighs depth. The modern online betting experience is designed to be optional, flexible, and lightweight, allowing everyday players to dip in and out without reshaping how they already consume sport and entertainment.
Why Betting Education Has Become Part of the Experience
As online betting has reached a wider audience, the need for clear, accessible explanations has grown alongside it. Many everyday players are not looking to master complex strategies or advanced terminology. They simply want to understand what they are doing before placing a small wager. That demand has pushed betting education into more mainstream, informal spaces, including podcasts, social media, and long-form video content.
This shift reflects a broader change in player expectations. Market research shows that first-time or casual bettors are far more likely to engage when rules and mechanics are explained in plain language. Concepts such as odds formats, point spreads, and parlays can feel opaque without context, especially for players who follow sport but have never interacted with betting systems before. Educational content lowers that friction, making participation feel less risky and more familiar.
YouTube has become a natural home for this kind of explanation. Long-form videos that walk through betting basics in a conversational way attract large audiences, particularly around major sporting events when curiosity peaks. Rather than treating betting as a specialist pursuit, these videos frame it as an extension of sports fandom that anyone can understand with a little guidance. For you, this kind of content reinforces the idea that modern betting is no longer reserved for experts. It is increasingly presented as something you can learn gradually, at your own pace, before deciding how or whether to participate.
What the Expansion of Online Betting Means Going Forward
The expansion of online betting reflects a broader shift in how people engage with sport and digital entertainment. For everyday players, the change is less about gambling more and more about having options that feel accessible, informed, and flexible. Betting now sits alongside fandom rather than replacing it, shaped by mobile access, clearer education, and tighter regulation. Market data shows that growth is being driven by casual participation, not extreme behaviour, which helps explain why betting continues to move into the mainstream. If this trajectory holds, online betting will remain a background feature of modern sports culture, something you can engage with occasionally, on your terms, without redefining how you follow the games you care about.
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