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New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
Also Interesting
Blue Jays Keep The Hot Stove Burning After Massive December Moves
The Toronto Blue Jays are certainly keeping things interesting this winter. While the calendar might say late December, the front office shows no signs of slowing down. They have already made waves across MLB with some massive acquisitions earlier in the month.
Rather than packing it in for the holidays, the management team is seemingly working overtime. Their goal is to build a roster that can truly compete for a championship in 2026.
Although there are no more signing announcements for the end of the year, the silence is likely temporary. Reports indicate that the team is actively pursuing several more roster improvements before the new year begins.
A Rotation Built To Dominate
The team made their intentions clear in early December. They successfully signed Dylan Cease to a massive seven-year, $210 million contract. This deal, which became official around December 8, instantly transforms the Toronto rotation into one of the strongest in MLB.
Moreover, they did not stop with just one big arm. The front office added significant depth by bringing in KBO MVP Cody Ponce on a three-year deal worth $30 million. This gives the team a level of stability that was missing in previous seasons.
With such dramatic changes to the roster, fans might be looking for a clear overview of licensed Ontario sportsbooks to understand how these moves have impacted the team’s championship odds. It is certainly a different looking team than the one that ended the last season.
Targets for the Bullpen and Lineup
It seems that the focus has now shifted from the starting rotation to other needs. Agents around the league note that the Jays remain “everywhere” in trade talks. The priority is now on finding high-leverage arms and position players to round out the squad.
The front office is reportedly looking at several specific targets:
- Robert Suarez is a primary target to help lock down the late innings.
- Luke Weaver is being considered to add veteran versatility to the staff.
- Depth pieces for the lineup are being sought to support the core hitters.
- Internal extensions remain a key part of the winter strategy.
Due to the heavy spending on Cease and Ponce, these next moves will likely be strategic. The team is looking for the right fit to complement their new stars.
The Future of the Infield and Management
Conversations are actively continuing with free agent Bo Bichette. Bringing him back is a major topic of discussion among the fanbase, even if no deal is imminent yet. Furthermore, the team has been linked to prospect Kyle Tucker, suggesting they are keeping an eye on the future as well as the present.
Manager John Schneider has also expressed optimism regarding his own contract extension. However, he made it clear that building the team comes first. Therefore, while the heavy lifting might seem done, the work continues behind the scenes.
To be sure, the MLB offseason is long. But the Toronto Blue Jays have started fast, and they seem determined to finish strong.
Also Interesting
BCU Financial: A Trusted Credit Union for the Ukrainian Community in Canada
We wanted to know what to do if you came to Canada for temporary or permanent residence. Many Ukrainians have arrived in the country, and many don’t know where to begin their financial journey. People often turn to traditional banks, where they encounter problems due to a lack of language skills and basic understanding of Canadian financial processes. We found an alternative – a credit union in Toronto. Today, we’ll look at one of the most well-known and learn more about what they have to offer Ukrainians.
What is a Credit Union in Toronto
These organisations differ from the typical bank for Ukrainians. They offer more flexible conditions, convenient online management, and a personalised approach.
However, these organisations are just as safe and reliable as banks. Let’s look at reliability using the example of the well-known BCU Financial:
- With over 70 years on the market. This credit union in Toronto has a dedicated client base with decades of experience.
- Extensive experience. Indeed, over more than 7 decades, its specialists have become experts in financial matters.
- Branches available. You can visit the office for face-to-face interaction.
- Active in the social life of the Ukrainian community. Buduchnist Credit Union provides financial support to schools, churches, and communication centres for Ukrainian newcomers.
As you can see, such companies have stability and experience. Now let’s look at how they differ from banks in financial matters.
Ukrainian Credit Union Toronto: Differences from a Traditional Bank
Firstly, such organizations welcome a personalized approach to Ukrainians. They are more flexible when it comes to obtaining a loan. Newcomers in Canada are working on receiving a good credit history. Banks always request one when reviewing a loan application.
Secondly, you can receive advice in your native language. Most Canadian banks don’t have multilingual consultants and respond only to inquiries in English or French. If, for example, you need help with a scholarship card, you’ll have to call a translator.
Third, you’ll get more flexible and understated banking for Ukrainians. It includes the ability to submit an app online. It provides such services as ordering credit cards, applying for a loan, or opening an account.
Conclusions
Credit unions are much easier for Ukrainians to work with. They speak your language, can provide advice on finances and their specific needs in Canada, and offer flexible terms. They also provide full-fledged online banking, so familiar to Ukrainians. You also become part of the community because, as a credit union member, you are, to a certain extent, its co-owner.
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