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Actor’s Death Raises Alarm about Off-Label Anesthetic

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7 minute read

From Heartland Daily News

By  Kevin Stone Kevin Stone

A federal court has indicted and charged five individuals for contributing to the death of actor Matthew Perry by providing him with the anesthetic ketamine.

On October 28, 2023, Perry was found floating face-down in his hot tub. An autopsy later revealed his death had been caused by “acute effects of ketamine.” Perry, a star of the television show Friends, had long struggled with addiction.

Charged in the 18-count indictment are Perry’s personal assistant, Kenneth Iwamasa; two doctors, Salvador Plasencia and Mark Chavez; and two other individuals, Erik Fleming and Jasveen Sangha. Sangha was known as the “Ketamine Queen” who is accused of running a North Hollywood “stash house.”

Multiple Players Charged

Documents filed by prosecutors claim Perry’s assistant and an acquaintance worked with the two doctors and the drug dealer to provide tens of thousands of dollars worth of ketamine to fuel Perry’s addiction. Fleming coordinated the sale with Sangha, prosecutors say.

Iwamasa provided at least 27 ketamine injections to Perry in the five days leading up to his death, according to the prosecution. Chavez admitted selling ketamine to Plasencia for redistribution to Perry by falsifying information to a distributor and then using a prescription written in the name of a former patient.

When Plasencia texted another doctor about how much to charge Perry for the ketamine, he wrote, “I wonder how much this moron will pay,” and “Let’s find out,” prosecutors say. The trial date for Chavez and Plasencia is set for March 4, 2025.

Binge-Use Temptation

Ketamine is a dissociative anesthetic that can produce hallucinogenic effects. Ketamine is also used as a pain reliever and for the relief of treatment-resistant depression.

Some people use ketamine as a recreational drug for its ability to induce hallucinations. The effects of ketamine are short-lived, and users may rapidly develop tolerance to the drug, leading some to binge-use it.

Celebrity Power, Vulnerability

Ketamine is widely accepted as safe and effective for use as an anesthetic in a clinical setting. Off-label uses of the drug that may lead to abuse have led to rising concerns.

A recent New York Times article questioned the drug’s safety for off-label use in the wake of Perry’s death. Although ketamine ordinarily carries no more risk than other anesthetics, pain relievers, and antidepressants.

Celebrities can use their fame and wealth to circumvent effective safeguards against over-prescription and abuse, says Devon Herrick, a health economist.

“Physicians have significant leeway to prescribe FDA-approved medications off-label,” said Herrick. “Some off-label therapies later become mainstream, while others fall out of favor. What makes Matthew Perry’s situation unique was his celebrity status. Similar to the experience of Michael Jackson, Perry was able to enlist the help of physicians willing to provide him with a risky drug therapy not appropriately monitored.

“It’s unlikely a noncelebrity patient would be able to find a doctor willing to administer an anesthetic in their home,” said Herrick. “The lure of both money and bragging rights to say they’re a celebrity doctor likely culminated in Perry’s demise.”

Off-Label Benefits

Ketamine was developed as an anesthetic agent and was found to help treat some mental health conditions through off-label use, which is a common procedure, says Jeffrey Singer, a senior fellow at the Cato Institute who defends off-label use of the drug.

“Roughly 20 percent of all drugs prescribed in the U.S. are for off-label uses,” said Singer. “The [Food and Drug Administration, FDA] has always deferred to clinicians and clinical researchers on how to use drugs off-label. Once the FDA approves a drug for a particular indication, it permits clinicians to use it for any other indication where clinicians and clinical researchers believe the drug can be helpful.”

This real-world experience brings important knowledge, says Singer.

“As clinical research and clinical experience continue, such off-label drug use can lead to subsequent therapeutic advances,” said Singer. “However, clinical researchers often discover over time that specific off-label uses do not work. Over time, we should learn a lot more about what conditions ketamine works best for and what are the optimal ways to use it for those conditions.”

The system is working, says Singer.

“There is no reason why the FDA should add to the already cumbersome regulatory regime by requiring further approvals for off-label uses,” said Singer. “The FDA should leave the off-label uses of drugs to clinical researchers, clinicians, and the civil tort system.”

Black Market Problem

Adding new legal barriers to ketamine prescription would probably drive those wishing to abuse the drug into the black market, where its use would be wholly unmonitored and more dangerous drugs are also readily available, says Singer.

“People are already getting ketamine in the black market, along with other psychedelics such as MDMA, psilocybin, DMT, and magic mushrooms,” said Singer. “If the FDA further restricted online sales [of ketamine], it would only intensify profits in the black market and drive people to the black market, where the purity and strength of these drugs are less certain.

“We already have seen reports of black market MDMA—“ecstasy” or “Molly”—being laced with fentanyl,” said Singer. “Further restricting online sales of ketamine—or limiting its off-label use by licensed clinicians—will only make it more dangerous for people who continue to use ketamine. But it will not prevent them from using it.”

Kevin Stone ([email protected]writes from Arlington, Texas.

 

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2025 Federal Election

Nine Dead After SUV Plows Into Vancouver Festival Crowd, Raising Election-Eve Concerns Over Public Safety

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Sam Cooper's avatar Sam Cooper

In Vancouver, concern about public safety — particularly assaults and violent incidents involving suspects previously known to police — has been a longstanding civic and political flashpoint

In an evolving mass-death investigation that could have profound psychological and emotional impacts on Canada’s federal election, Vancouver police confirmed Sunday that nine people were killed Saturday night when a young man plowed a luxury SUV through a festival block party in South Vancouver, leaving a trail of instant deaths and horrific injuries, with witnesses describing convulsing bodies and wounded toddlers in the aftermath.

The driver, a 30-year-old Vancouver resident known to police, appeared to be shaken and apologetic, according to eyewitness accounts and video from the scene. Authorities stated the case is not being treated as terrorism.

Late Saturday night, Vancouver police confirmed at a news conference that the man, who was known to police “in certain circumstances,” had been arrested.

The incident occurred around 8:14 p.m. during the annual Lapu Lapu Festival, a celebration of Filipino Canadian culture held near East 41st Avenue and Fraser Street. Thousands of attendees had packed the area for cultural performances, food stalls, and community events when the luxury SUV entered the closed-off area and accelerated into the crowd. Photos of the vehicle, with its doors ajar and a crumpled front end, indicate it was an Audi Q7 with black tinted windows.

In Vancouver, concern about public safety — particularly assaults and violent incidents involving suspects previously known to police — has been a longstanding civic and political flashpoint. Saturday’s tragedy sharpened those anxieties, potentially influencing the attitudes of undecided voters in a federal election that has focused on social disorder and crime framed by the Conservative side, with the Liberal frontrunners countering that firmer sentencing laws would undermine Canada’s Charter of Rights.

Witnesses to Saturday’s tragedy described scenes of chaos and terror as the SUV slammed into festival-goers, accelerating through the crowd.

“I thought it was fireworks at first — the sounds, the screams — then I saw people flying,” one witness told reporters on the scene.

Authorities have launched a full criminal investigation into the suspect’s background, including previous interactions with law enforcement.

The tragedy unfolded during the final, high-stakes weekend of Canada’s federal election campaign, throwing public safety and political leadership into sharp relief.

On Saturday night, before news of the Vancouver incident broke, Conservative leader Pierre Poilievre posted a message on X at about 10 p.m., declaring, “This election comes down to one word. Change. Our Conservative plan will bring home an affordable life and safe streets — For a Change.”

Meanwhile, Liberal leader Mark Carney, campaigning in the Greater Toronto Area, posted at roughly the same time, “Dropped in on dim sum today in Markham. The best part of this campaign has been meeting Canadians in their communities — and hearing how excited they are about our future.”

As the scale of the tragedy became clear, both leaders shifted sharply in tone.

Poilievre posted again around 1 a.m. Sunday, writing, “I am shocked by the horrific news emerging from Vancouver’s Lapu Lapu Day Festival tonight. My thoughts are with the Filipino community and all the victims targeted by this senseless attack. Thank you to the first responders who are at the scene as we wait to hear more.”

Carney, who had posted shortly before midnight that, “We don’t need anger. We need to build,” followed with a direct statement on the Vancouver attack around 2 a.m. Sunday morning, writing, “I am devastated to hear about the horrific events at the Lapu Lapu festival in Vancouver earlier this evening. I offer my deepest condolences to the loved ones of those killed and injured, to the Filipino Canadian community, and to everyone in Vancouver. We are all mourning with you.”

Online, the tragedy quickly reignited concerns about violent crime, bail, and the rights of offenders — issues that have increasingly polarized Canadian political debate.

In response to Carney’s statement, a comment from an account named Willy Balters reflected the growing anger: “He’ll be out on bail by morning right?”

Another commenter, referencing past political controversies over judicial reform, posted to Carney, “You stood behind a podium and declared murderers’ Charter Rights can’t be violated.”

The raw public sentiment mirrored broader criticisms that Canada’s criminal justice system — and its perceived leniency toward repeat offenders — has failed to keep Canadians safe.

Just days prior, a different incident tapped into similar public anger. B.C. Conservative MLA Elenore Sturko posted, “A visitor to Vancouver was brutally attacked by a man only hours after he was released on bail for assaulting police and uttering threats. @Dave_Eby — is this the kind of welcome visitors to FIFA will have to look forward to? BTW, this violent man is out on bail AGAIN!”

That incident continued to draw heated social media on Sunday, with David Jacobs, a well-known conservative-leaning commenter, posting, “A man, while out on bail for assaulting a peace officer, violently assaulted a woman. He’s out on bail again. The Liberals put criminal rights far ahead of victim rights and community safety. Stop the insanity. Vote for change!”

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2025 Federal Election

Police Associations Endorse Conservatives. Poilievre Will Shut Down Tent Cities

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From Conservative Party Communications

Under the Lost Liberal decade, homelessness has surged by 20% since 2018 and chronic homelessness has spiked 38%. In cities like Nanaimo, Victoria and London, the number of people living in tents and makeshift shelters has exploded. In Toronto alone, there were 82 encampments in early 2023—now there are over 200, with an estimated 1,400 in Ontario.

Yesterday, Conservative Leader Pierre Poilievre received the endorsement of the Toronto Police Association, the largest single association of its kind in Canada, representing approximately 8,000 civilian and uniformed members.

This follows the endorsement by the police associations of Durham, Peel, Barrie, and Sault Ste. Marie of the Conservative plan to stop the crime and keep Canadians safe, after the Liberal government’s easy bail and soft-on-crime policies unleashed a wave of violent crime.

“These men and women put their lives on the line every day to keep our streets safe,” Poilievre said. “Our Conservative team is honoured to have their support and will back them up with laws to help them protect all Canadians.”

Poilievre also announced that a new Conservative government will ensure that police have the legal power to remove dangerous encampments to end the homelessness and the mental health and addiction crisis that has trapped thousands in dangerous tent cities and make life unsafe for law-abiding Canadians who live near them.

“Parks where children played are now littered with needles. Small businesses are boarded up and whole blocks of storefronts are shuttered because their owners can’t afford to deal with constant break-ins and vandalism,” Pierre Poilievre said. “Public spaces belong to everyone, but law-abiding citizens, especially families and seniors, are being pushed out to accommodate chaos and violence.”

Canadian cities have a mixed record of dealing with encampments in public places, with some not acting because they don’t believe they have the legal authority to remove the camps. Conservatives will work with provinces and ensure law enforcement has the clear legal tools they need to remove encampments and give Canadians back the safe streets and public spaces they deserve.

A Poilievre-led government will do this by reversing the Liberals’ radical pro-drug policies and by:

  • Amending the Criminal Code to give police the tools to charge individuals when they endanger public safety or discourage the public from using, moving through, or otherwise accessing public spaces by setting up temporary structures, including tents.
  • Clarifying in law that police can dismantle illegal encampments and ensure individuals living in them who need help are connected with housing, addiction treatment, and mental health services.
  • Giving judges the power to order people charged for illegally occupying public spaces with a temporary structure and simple possession of illegal drugs to mandatory drug treatment.
  • Returning to a housing first approach to homelessness, ensuring people get off the streets into a stable place to live with the support they need to rebuild their lives.

Under the Lost Liberal decade, homelessness has surged by 20% since 2018 and chronic homelessness has spiked 38%. In cities like NanaimoVictoria and London, the number of people living in tents and makeshift shelters has exploded. In Toronto alone, there were 82 encampments in early 2023—now there are over 200, with an estimated 1,400 in Ontario.

These encampments are a direct result of radical Liberal policies such as drug decriminalization and unsafe supply. They are extremely dangerous for the people trapped in them, who endure overdoses, assaults, including sexual assaults, human trafficking, and even homicide, as well as the community around them.

Under the Poilievre plan, tent cities will no longer be an option—but recovery will be. Conservatives will give law enforcement the tools they need to help clean up our streets, deal with chronic offenders, and provide truly compassionate recovery and treatment where it is needed.

“Instead of getting people the help they need, the Liberals abandoned our communities to chaos,” Poilievre said. “Leaving people trapped by their addictions to live outdoors through Canadian winters, sick, malnourished, cold, wet and vulnerable is the furthest thing from compassionate.”

A Conservative government will also overhaul the Liberals’ dangerous pro-drug policies that have led to over 50,000 overdose deaths over the Lost Liberal Decade. Instead of flooding our streets with taxpayer-funded hard drugs, we will invest in recovery to break the cycle of despair and offer real hope.

Conservatives will allow judges to sentence offenders to mandatory treatment for addiction, and we will fund 50,000 addiction treatment spaces, ensuring that those struggling with substance use get the support they need to recover—because real compassion means helping people get better, not enabling their suffering.

In addition to these measures, Poilievre has a plan to end the soft-on-crime approach of the Lost Liberal Decade, end the chaos, and restore order and safety across Canada:​

  • Three-Strikes-and-You’re-Out Law: Individuals convicted of three serious offences will face a minimum prison term of 10 years and up to a life sentence, with no eligibility for bail, probation, parole, or house arrest.
  • Mandatory Life Sentences: Life imprisonment for those convicted of five or more counts of human trafficking, importing or exporting ten or more illegal firearms, or trafficking fentanyl.
  • Repeal of Bill C-75: Ending the Liberals’ catch-and-release policies to restore jail, not bail, for repeat violent offenders.
  • New Offense for Intimate Partner Assault: Creation of a specific offense for assault of an intimate partner, with the strictest bail conditions for those accused, and ensuring that murder of an intimate partner, one’s own child, or a partner’s child is treated as first-degree murder.
  • Consecutive Sentences for Repeat Violent Offenders: So there will no longer be sentencing discounts for multiple murderers.

Canadians can’t afford a fourth Liberal term of rising crime and chaos in our streets. We need a new Conservative government that will end the chaos, restore order on our streets and bring our loved ones home drug-free.

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