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23andMe; The True Meaning of Family

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I had seen ads many times on my Facebook feed from 23andme, and I have wanted to do it for a long time. The kits offer ancestry breakdown and personalized health insights which have always intrigued me. After all, from the depths of my core, I believe nothing is more important than family.

My desire to know more might be hard for someone to understand, looking from the outside. My god, some people on the inside don’t understand either. They might ask, “How can someone who professes to love her family be estranged from so many of her family members?” From my perspective, I lost my dad, my mother, my sister, and my brother due to alcoholism even though some of them are still alive.

My mom and dad married just before I was born in 1968. After having my brother and my sister, they divorced when I was eight or nine, due to my father’s problem with alcohol. My brother, Brett, my greatest friend, became another alcoholic branch on our family tree and lost his long courageous battle with addiction and mental illness when he was 39.

I had a relationship with my parents and sister until well into my thirties. Not a perfect one, as relationships within the walls of families can be challenging, but a life that included them. I loved them all very much. Even so, our immediate family unit dissolved under the stresses of my brother’s addiction as well as many unhealthy family patterns and blame-shifting. It all became too much.

My brother alone is responsible for his alcoholism; our reaction to it was never his responsibility. For many reasons, including my wellbeing and that of my husband and my two young sons, I made the painful decision to love my father, mother, and sister from afar. I ceased all contact more than ten years ago.

Through years of therapy, I worked extremely hard to be healthy and happy. I had spent too many decades making poor decisions and looking after other people. Finally, I found the courage to look after the needs of my own family first—my husband and sons. And I am most proud to say that I finally looked after myself; I responded to my own needs. That wasn’t and isn’t selfish. For my own mental health it was necessary.

I have always known my dad’s side of the family came from England, as we are all very close, but my excitement and hope in ordering the 23andme kits was to learn a little more about my mother’s side of the family. Growing up I only ever met my mom’s parents, her sister, and that sister’s children, my two cousins. I never met, nor did my mother ever mention, any of her aunts, uncles, cousins, or even grandparents.

My husband of 30 years, Jim, agreed that it would be amazing to learn more about where our families originated. He knows his family came from England too, whereas I was excited with the possibility of knowing where my mother’s parents came from. I had been close to them, as were my brother and sister, but we lost our grandparents when we were still young. My nana died from dementia complications when I was only 18, and my papa died when I was around 25 or 26. I feel blessed that Papa got to meet and spend time with his two great-grandchildren, Rick and Ryan, before he passed away.

Last November my husband and I opened our kits, filled the little tubes with saliva, and sent them off in the mail. I waited. And waited. And waited some more. I was so eager to get the results, like a kid waiting patiently to open a Christmas present, and I was disappointed when they didn’t update the information on my online portal as quickly as they had originally promised. Finally, the results arrived on January 15, 2022. I was a little sad as the data seemed a little vague. It confirmed that my relatives came from England, yet there wasn’t much other information. I was looking to know more about my nana and papa, maybe something more exotic, but I suppose that is where their families originated too.

So, after looking it over and analyzing my health data I logged out of my 23andme portal and I doubt I ever would have thought more about it or logged in again.

I was at work just a few weeks later, on February 7, when my phone beeped with an email that had a 23andme logo: “Hey Jodee, My name’s James Dodds and 23andme says that we may be half siblings. My dad, Jim Dodds, was from Ponoka so I am wondering if that’s the connection.”

I was completely calm as I read and responded within ten minutes to this unexpected news. I know everyone is different, but for me I have experienced firsthand how my body and mind reacts when being in shock. After all, I remember clearly when two police officers came to my front door in the middle of the night to tell me my brother had taken his own life. When I shared it with my husband that evening and with my two adult sons, now 29 and 31, they didn’t quite comprehend what it could mean. I knew instantly, not because I could have ever imagined such a thing or that there was a hint of some deep dark family secret, because there wasn’t. I live now, as I did as a young child with my parents, very close to Ponoka, Alberta. This wasn’t someone emailing me from halfway across the world, this was 20 minutes away. DNA doesn’t lie.

The initial shock had worn off by that evening. Random visions started going through my mind, causing floods of tears. My fully clothed dad saving me from drowning when I walked off the edge of a pier during a summer vacation when I was probably five years old. My grandma’s face—it sits in a beautiful frame in my office. Big Tisdale Christmas get-togethers with everyone from my dad’s side of the family at my house. My earliest memory of looking inside eggs with a red light with my grandfather when I was three or four. Being the oldest grandchild. Memories and tears. More memories and tears. And finally, my dad’s siblings—Uncle Les, Auntie Myrna, and Auntie Mary—all of whom have stood by me and supported me through my life’s journey. Never, not once, judging or condemning me or taking sides when it came to my complicated relationship with my father. They have loved me unconditionally, while loving their brother too. I LOVE my family.

Along with the tears came the overwhelming sense of disbelief and pain. My heart has been shattered.

My whole life flashed before my eyes. I knew my mother was pregnant when she got married to my father and since the whole marriage wasn’t blissful, we never talked about any other details after they divorced. As I tried to unwrap all my feelings, not knowing whether my mother lied or took her best guess and married my dad, I had no feeling of rage when I texted her: “I would like to know please your connection (and/or relationship with a Jim Dodds). I don’t need a long story. I don’t need contact with you. Just a simple one or two sentence answer. I would appreciate if you could get back to me within a day as this is time sensitive. Thank you.”

I am aware that this would come to her as much of a shock after 53 years as it did to me. But our estrangement complicated matters and her shock isn’t my responsibility. So, once again, I waited. And waited. And waited some more. It seemed like days, but in fact it was the next morning when I received a reply from my mother: “The only Jim Dodds I ever knew, I dated someone with that name when I was 18.”

I was already sure it was true. He is my biological father.

I don’t think anyone would ever blame me if my initial reaction would be hating my mother. You don’t have to be estranged for that. I think to myself even in the closest of families, this surprise revelation could ruin a mother and daughter relationship and cause tremendous upset. I am as imperfect as anyone, but I never react based on hate or anger. I am not even capable of feeling those emotions.

Life is full of twists, turns, losses, happiness, and hardships. I have lived through my fair share of pain, and this is no different. Pain is not a contest. We all experience it, and there are many different reactions. Sadly, often it is human nature when something bad or traumatic happens to be furious or to want to hold someone else responsible. We blame ourselves, we blame others, sometimes people blame god, but following those emotions will only keep us angry, unhealthy, and stuck in the same place. Instead, I always have a deep-seated hope for everyone, regardless of circumstance, to find the strength to follow empathy, compassion, understanding and love because that path leads to peace. Being all of those things never means that you have to accept relationships that are not good for your own health, happiness, and spirit but I never make important life’s decisions based on toxic emotions.

And so, in following with my head and also my heart, I met with my mother, the first time I have seen her face in nine years.

I don’t know the future of the relationship between me and my mom or if there will even be one. Before our visit, a lot of damage had been done that I am unsure can be reversed but I am putting all of that aside for today. As I share this revelation, I stand beside my mother as I believe her when she says there was no ill intent. She had been dating a bull rider, Jim Dodds, and loved him. But she was so young and had already experienced trauma of her own and had a past with my father. They had a daughter together four years before I was born, in 1964, who was given up for adoption. That connection was why my mom started seeing my dad again. And when she got pregnant at 19, she broke things off with Jim, and told him she was getting married without ever mentioning her pregnancy. With her whole heart she believed my dad was my biological father.

I have cried a million tears the last couple weeks, had many sleepless nights, and swam hundreds of lengths at the pool downtown in Sylvan Lake to calm my mind. And what I realized is that family is so much more than being related by blood. It is about being there for each other, through the good times, and especially the bad. It is the relationships in our lives that provide a sense of security and belonging. It is people that hold your heart gently in their hands. It is about feeling you are in a safe space, never worried someone won’t love you, no matter what you share. Family is about feeling valued, respected, and understood. It is about bumps in the road yet creating memories that are built on pure, unconditional love. Family is being able to say you are sorry when someone says you hurt them.

I am incredibly blessed to have so many relationships in my life that provide all these things and more, many of whom are friends that I wholeheartedly consider my family. We live in a beautiful world, where children continue to be adopted, people get divorced and then remarried with blended families, foster parents, surrogacy, and IVF sometimes with anonymous donors. Even same sex couples are fulfilling their dreams of becoming parents. There are many scenarios, and all of those people are no less loved, no less connected and no less family than those that share DNA. I always knew this; it just took a few days to catch my breath.

As much as my dad and I had our own challenges throughout the course of our lives, I loved him very much. This is not a win for me. I never, not once, wished for or longed for a different father. He passed away in February 2018. As much as our own conflicts and estrangement, I think this would have broken his heart.

I am still continuing to process, and my biggest source of pain and disbelief right now, is that my biological father Jim passed away on February 18, 2021, just over a year ago from cancer. He will never know that I was born. We will never get the opportunity to meet and he will never know his amazing grandsons.

There is no regret from me or desire to change the course of any of our lives, because, had my mom, my dad, or Jim Dodds known, the alternative would be worse than what we are all faced to accept today. Any other decision would change the course of so many different lives. Others quite likely would never have been born, such as my newly discovered half-siblings Jaime, James, and Jade as well as the brother I lost ten years ago. So as hard as it is to work through all of my emotions, things worked out as they should.

For me, I would never want to alter the course of fate. I love my family and was always meant to be the sister of Brett Tisdale

 

Author of the powerful memoir The Sun is Gone: A Sister Lost in Secrets, Shame and Addiction and How I Broke Free. Outspoken advocate to help eliminate the shame + stigma surrounding Addiction + Mental Health. Visit www.jodeeprouse.ca or follow on instagram @jodeeprouse

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9 Things You Should Know About PK/PD in Drug Research

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How do scientists know the right dose of a drug? How long does it stay in the body? And how does it actually work once it gets there?

The answers lie in PK/PD—short for pharmacokinetics and pharmacodynamics—two key concepts that shape how medicines are developed, tested, and refined.

To understand how these two fields guide drug research, it helps to break down what each one actually means.

1. PK/PD Defined in Plain Terms

Pharmacokinetics (PK) tracks what the body does to a drug—how it’s absorbed, distributed, metabolized, and excreted. In contrast, pharmacodynamics (PD) looks at what the drug does to the body—its biological effects and how those effects change with dose or time.

Together, they help researchers fine-tune every stage of drug development—from preclinical studies to dosing decisions.

2. Why Timing Is Everything in PK

Timing isn’t just important; it’s everything. PK shows you how fast a drug gets into the bloodstream, how long it stays active, and when it leaves the body.

That knowledge drives key decisions about medication schedules. Should it be taken once a day or several times? Swallowed or injected? The PK profile helps answer those questions.

PK also makes it possible to track how drug concentrations rise and fall over time, depending on the dose and how the body processes it. Finding the right balance—enough to be effective but not enough to cause harm—is key to designing safe and effective clinical studies.

3. PD Tells You If a Drug Works

Once the drug reaches its target, PD shows what kind of response it triggers in the body. Does it bind to the right receptor? Block a harmful process? PD helps you measure those effects and determine if the drug is doing what it’s supposed to do.

PD data also helps identify when that response starts to fade or becomes too strong. It’s useful for assessing if the drug’s action is strong enough, lasts long enough, and stays within a safe range.

4. PK/PD Models Guide Early Decisions

Before human trials begin, PK/PD modeling is used to predict how a drug might behave in the body. It often relies on preclinical data from animal studies and can simulate a variety of conditions, including how a drug may act in individuals with critical illness.

To use these tools effectively, researchers often consult expert-developed resources that cover essential PK/PD modeling techniques, from foundational principles to advanced applications.

With strong modeling skills, it becomes easier to identify potential issues early, optimize clinical study design, and reduce trial-and-error. This leads to more focused, efficient early-phase research.

5. Animal Data Isn’t Enough

Animal studies provide an important starting point in drug research. They can reveal how a compound behaves and highlight possible risks, like toxicity or poor absorption. But since animals and humans process drugs differently, their results don’t always translate directly.

This is where PK/PD analysis becomes critical. It helps adjust and interpret preclinical findings in a way that’s relevant to human biology. Accurate bioanalytical methods are also needed to track how drugs move through different systems. Without that, early signals could be
misleading.

6. PK/PD Supports Personalized Treatment

People vary in how they respond to medications. A dose that’s right for one person might be too strong—or too weak—for someone else. PK/PD allows for adjustments based on individual factors like age, weight, liver or kidney function, genetics, and other medications.

This kind of personalization improves safety and effectiveness, and it’s becoming an increasingly common goal in clinical pharmacology.

7. Regulatory Agencies Want PK/PD

PK/PD data has become a core part of regulatory review. Agencies like the Food and Drug Administration (FDA) and other regulatory authorities around the world look for this information in drug submissions. It helps explain how a drug works, how its dosage was chosen, and how
safe it appears to be.

This data also supports study design, safety assessments, and the information included on the final drug label. Submissions without it are more likely to face questions, delays, or rejections.

8. PK/PD Helps Uncover Safety Issues

While PK/PD is often associated with measuring effectiveness, it also plays a significant role in identifying safety concerns. It can reveal issues like drug accumulation, interactions with other medications, or delayed side effects.

By connecting drug exposure to those risks, adjustments can be made early, well before the drug reaches a broader population. That leads to safer trials and better long-term outcomes.

9. PK/PD Keeps Evolving

The field of PK/PD is advancing quickly. Better tools and smarter technology are changing how drug behavior is modeled and understood. Machine learning, big data, and improved bioanalytical methods are making it easier to anticipate how drugs will perform under real-world
conditions.

These advances support more reliable predictions and allow teams to adapt faster, either during early testing or when refining late-stage development plans.

Final Thoughts

PK/PD may seem technical at first, but its value is hard to miss. It plays a critical role in making sure new drugs are safe, effective, and precisely delivered. Understanding how these principles guide drug research offers a clearer view of the science behind the medicines we depend on.

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Endorphina Slots: High-Quality Games Now at Zoome Casino Canada

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If you’re looking for a provider that blends striking visuals, solid math models, and engaging themes, Endorphina slots are a must-try. Now featured at Zoome casino, Endorphina is quickly becoming a favourite among Canadian players who enjoy well-balanced volatility and great return potential.

From classic fruit machines to themed adventures with expanding wilds, Endorphina in casino environments offers reliable entertainment and serious payout opportunities. But what makes these games stand out? Let’s break down the key features, winning potential, and why you should play Endorphina games at Zoome.

Who Is Endorphina?

Endorphina is a leading game provider based in Prague, with over a decade of experience in developing online slots for regulated markets. The company is known for its well-polished video slots that balance engaging storylines with player-friendly mechanics. Their catalogue includes over 100 titles, with new releases launched regularly.

In Canada, Endorphina slots are now widely accessible through Zoome casino, one of the country’s fastest-growing platforms with a large game library and crypto-friendly payments.

Popular Endorphina Slots You Can Try at Zoome

Once you complete your zoome casino login, head over to the Endorphina slots section to discover a curated list of titles. Here are some fan favourites:

1. Hell Hot 100

● RTP (Return to Player): 96.07%
● Volatility: Medium
● Max Win: 1,000x
● Type: Classic fruit slot with a hot twist
● Why Play: Simple gameplay, blazing fast spins, and high hit frequency

2. Chance Machine 100

● RTP: 96.00%
● Volatility: Low to Medium
● Max Win: 5,000x
● Features: Expanding wilds, stacked symbols
● Why Play: Perfect for casual players who want frequent wins

3. Book of Santa

● RTP: 96.00%
● Volatility: High
● Max Win: 5,500x
● Features: Free spins with expanding symbols
● Why Play: A seasonal slot that pays like a timeless classic

4. Tribe

● RTP: 96.00%
● Volatility: Medium to High
● Max Win: 3,000x
● Special Feature: Free spins with progressive multipliers
● Why Play: Visually beautiful with strong payout structure

All endorphina games are built with HTML5, ensuring smooth play on desktop and mobile without requiring downloads.

Are There Endorphina Free Slots?

Yes! Endorphina free slots are available for demo play directly on Zoome. This means Canadian players can try out their favourites before making a real-money commitment. Free versions include all the same features, visuals, and mechanics — great for getting familiar with a game’s volatility and bonus structure.

To access, simply log in or click the “Demo” button on any title from the Endorphina section on Zoome.

Zoome Casino Bonuses and Endorphina Integration

Zoome casino offers several bonuses that can be used specifically on Endorphina slots, including:

● Welcome bonuses with free spins on selected Endorphina titles
● Reload bonuses for returning players
● Cashbacks and weekend tournaments featuring endorphina slot themes
● Seasonal campaigns with exclusive zoome casino promo codes

New players should check for a potential zoome no deposit bonus, as it occasionally applies to Endorphina’s most popular games like Book of Santa or Hell Hot 100.

RTP, Win Rate & Performance Metrics

Endorphina designs its games with a balance of fairness and entertainment. Here’s a general breakdown:

Metric Range/Typical Value

RTP 96.00% – 96.07%
Average Hit Frequency ~1 in 4 spins
Max Exposure (Base Game) 1,000x to 5,500x
Bonus Trigger Frequency 1 in 120–150 spins (approx.)
Average Session Duration 15–25 mins (based on volatility)

These stats make Endorphina in casino environments appealing to both casual players and slot grinders who understand variance and bankroll management.

Play Anywhere, Anytime

Zoome supports mobile-first gameplay. Every endorphina slot loads seamlessly on iOS and Android without needing an app. With fast servers, secure encryption, and a clean layout, spinning is quick, intuitive, and glitch-free.

Whether you’re chasing a bonus round or enjoying a few free spins on your lunch break, Zoome makes the experience smooth and hassle-free.

Final Thoughts

With its mix of quality graphics, strong RTP, and easy bonus access, Endorphina slots are a solid choice for Canadian players. Whether you’re trying endorphina free slots in demo mode or diving into real-money play via zoome casino login, there’s a title to suit your style.

From well-known hits like Hell Hot 100 to sleeper favourites like Tribe, this provider continues to prove why Endorphina in casino settings is a winning combination. And with regular zoome casino promo code campaigns and potential zoome no deposit bonus access, it’s the perfect time to start spinning.

Ready to explore the full lineup? Visit Zoome and see what Endorphina has to offer — your next big win could be one spin away.

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