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Public use of masks to control the coronavirus pandemic

(Originally published March 29 by Longrich Paleo Lab)

Nicholas R. Longrich, PhD

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

The Longrich Paleontology Lab is part of the Milner Centre for Evolution at the University of Bath. We use fossils to understand large-scale evolutionary change in organisms and ecosystems. 

The US and UK governments, as well as the World Health Organization, currently advise against the use of masks by the public to fight the ongoing Coronavirus Disease 19 (COVID-19) pandemic (1). But could they be wrong?

The governments of China, South Korea, Hong Kong, Viet Nam, Czechia, Slovakia, Bosnia and Taiwan all recommend that the public wear masks to slow the spread of the coronavirus. In some countries, like Japan, masks aren’t officially recommended, but are still widely used by the public. Many countries treat masks as a strategic resource. China has ramped up production of facemasks, converting Foxconn factories that once made iPhones to make face masks. Taiwan has also ramped up the production of facemasks, prohibited their export, and implemented price controls and rationing. It’s hard to see how both approaches could be right. Increasingly, advice against the use of face masks has been questioned (1) (2) (3), including by the head of China’s CDC (4). Austria has recently moved to make mask wearing in public obligatory, and in the United States, the CDC is now debating their use.

Common sense, scientific studies, but perhaps most of all the success of countries using masks to fight the coronavirus suggest that masks may make a difference. There are fewer scientific studies available to guide decision making than we might like, and the evidence is not always clear-cut. However, decision-making in a crisis requires that decisions be made in the absence of perfect clarity. What is clear is that the exponential mathematics of pandemics mean that even if masks are of limited benefit in reducing infection rates, masks could make a large difference over time, potentially slowing the pace of the pandemic, limiting its spread, saving lives, and finally, letting countries to restart the economies that their people depend on for their livelihoods.

Figure produced by Johns Hopkins University using data from Worldometers on March 29.

Masks protect you from others, others from you

It seems sensible to assume that any barrier between two people’s airways reduces the chance of an air-borne virus being transmitted between them. Masks worn by infected people catch some fraction of virus-laden respiratory droplets that are released by breathing and coughing. Perhaps just as important, breathing through a mask slows and deflects air as it is exhaled, potentially reducing the distance that viral droplets travel as aerosols.

Meanwhile, masks worn by uninfected people catch a fraction of the virus they’d otherwise inhale. If both infected and uninfected people wear masks, then these effects multiply. For example, hypothetically, if an infected person’s mask reduces the amount of virus spread by 75%, and the uninfected person’s mask reduces it by another 75%, then the total reduction of the virus spread is 94%.

It’s still possible that this reduction isn’t enough to prevent infection. However, masks could still protect people— because dosage matters. Lower dosing of virus means infection takes longer to build up, giving the immune system time to mount a response.

The immune system fights viruses, like a farmer trying to remove weeds from his field. How difficult those weeds will be to control depends on how many seeds there are. 1000 seeds in a field might not be a challenge, but 1,000,000 or 100 million make weeding far more difficult. In the same way, even when masks fail to prevent infection, by lowering the initial dose of virus they could  conceivably make the difference between mild symptoms and a severe illness requiring hospitalization, or even leading to death.

Models suggest masks could work to control pandemics

Of course, it’s possible that masks might have only limited benefit in stopping the spread of COVID-19— for any number of reasons.  Masks might provide limited protection, because they are less effective than suggested by some studies, because people misuse them, because of shortages of effective masks like surgical masks and N-95s— or all of these.

But to understand how they could still make a difference, we have to consider masks in the context of small reductions in viral transmission rates. Consider how epidemics grow— exponentially. Allowed to spread unchecked, one case of Covid-19 becomes 2.5 (assuming for this model an R0 of 2.5), each case causing 2.5 more, and so on. Over the course of 15 reproductive cycles, each taking 7 days, or about 3 months in total, one case becomes 2.5 x 2.5 x 25… or 2.5^15 =   931,323 cases (Fig. 1).

Figure 1. A simple model showing exponential growth in an uncontained outbreak over time (generation time = 7 days, R0 = 2.5) and with small reductions in the reproductive rate R.

Now, let’s suppose widespread use of masks cuts the growth rate by just 10%. Each person now infects 2.25 others, who infect 2.25 others, and so on. Over 15 cycles, 2.25^15 = 191,751 cases. An 80% reduction. Understanding this exponential growth explains how the virus caught the world by surprise even as the pandemic was monitored in real time. Exponential growth just doesn’t make sense, until you do the numbers, and even, they’re still hard to believe. But another counterintuitive aspect of exponential growth is that small decreases in the exponent greatly slow growth. A 10% increase in the exponent can have a massive effect, but even a limited intervention, with a 10% decrease over time, pays large dividends (Fig. 1).

These are very, very simple models. But sophisticated modeling also shows large scale use of masks could slow, even stop pandemics. A 2010 study found that above a certain threshold, widespread use of effective masks can reduce the reproductive number (R) of an influenza virus below 1, and the pandemic stops (25). If face masks were highly effective (well-designed, used properly and consistently), then public use of masks could stop a flu pandemic if used by just 50% of people. If masks were less effective, more than half the population would have to wear them to stop the pandemic. If masks were highly ineffective, they could flatten the curve of the epidemic, but wouldn’t stop it (25). We don’t know which model is most accurate. But does it even matter? In the context of the current pandemic, any of these scenarios would be a huge win.

Real world experience suggests masks work in pandemics

The most compelling evidence of the potential effectiveness of masks in the fight against COVID-19 comes from their use in the real world. Places that have controlled their coronavirus epidemics most effectively – China, South Korea, Hong Kong, Taiwan, Vietnam, Singapore, Kuwait, Czechia, Slovakia, Japan- use masks (Fig. 2). Aside from China, which was the epicenter of the pandemic and so played catchup in developing and implementing its strategy, virtually all of the worst outbreaks are in Western countries that officially advise against mask use, and where there is little culture or practice of mask wearing.

Figure 2. Western countries (US, Canada, Australia, UK, Western Europe) versus countries and territories using masks as part of official government or in practice policy (China, South Korea, Japan, Hong Kong, Taiwan, Vietnam, Thailand, Kuwait, Slovakia, Czech Republic, in blues and greens). Countries with official or unofficial policies of mask usage have controlled the outbreak far better than those without. Note that Austria currently uses masks but has only revised its official policy recently.

Places like China, South Korea, Taiwan, Vietnam, Kuwait, Czechia and Singapore differ greatly in political organization, ranging from communism to democracies, and also in their level of economic development and population density. And strikingly, these countries also differ in their suppression strategies. China implemented a lockdown of Wuhan, shut down industry nationwide, implemented temperature checks and social distancing, tested extensively— and employed masks. Korea responded with an aggressive testing and contact tracing—and masks. Japan has done far less extensive testing than Korea, but shut down schools and large gatherings— and used masks. The pandemic management strategies used by these countries far more diverse than has been appreciated. Arguably one of the few things all these successes share is widespread wearing of masks. And on the other hand, one common factor shared by the pandemic suppression strategies of the US, Canada, the UK and Europe is the decision to discourage the use of masks by the public. This evidence doesn’t prove, but it does very strongly hint that masks are a critical part of these country’s suppression strategies. And by watching countries like Austria that have recently revised their policies, we can test this idea.

What kind of mask? Surgical masks as good as N95s; are improvised masks better than nothing?

Would cloth masks work? Research into the effectiveness of cloth masks is limited  (34). Existing research shows homemade masks are- unsurprisingly- inferior to surgical masks. However, they appear to be better than nothing. One laboratory study found homemade masks were half as effective as surgical masks in filtering particles (35). Another study found homemade masks made from various materials stopped virus aerosols, but less well than surgical masks (36). A surgical mask stopped 90% of viral aerosol particles, a dish towel, 72%, linen, 62%, and a cotton T-shirt, 51% (36).

Conclusions

Strong scientific evidence and rational arguments exist for the widespread, public use of facemasks. The principle behind facemasks- they reduce the amount of virus exhaled by infected people, and inhaled by uninfected- suggest they should be a primary tool in combating any respiratory virus. Scientific research, including experimental studies, retrospective studies of the SARS epidemic, hospital studies of COVID-19, and modeling studies, all suggests masks are likely to be effective in controlling the pandemic. Most importantly, the experience of countries using masks against SARS and the current coronavirus pandemic imply that they are effective when used by the public. However, modeling studies and the real-world experience of countries like China and South Korea suggests that neither masks, nor anything else, provides a magic bullet against a pandemic. So strategies should not rely on any single intervention, but rather a wide range of interventions, potentially including masks. Further research and open debate on the effectiveness of masks and other strategies are urgently needed.

(Originally published March 29 by Longrich Paleo Lab) Nicholas R. Longrich, PhD

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