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3 win chemistry Nobel; findings led to bestselling drug

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STOCKHOLM — Three researchers who “harnessed the power of evolution” to produce enzymes and antibodies that have led to a new bestselling drug and biofuels won the Nobel Prize in chemistry on Wednesday.

Frances Arnold of the California Institute of Technology was awarded half of the 9-million-kronor ($1.01 million) prize, while the other half will be shared by George Smith of the University of Missouri and Gregory Winter of the MRC molecular biology lab in Cambridge, England.

The Royal Swedish Academy of Sciences, which chose the winners, said Arnold, 62, conducted the first directed evolution of enzymes, whose uses include “more environmentally friendly manufacturing of chemical substances such as pharmaceuticals and the production of renewable fuels.”

Smith, 77, developed a method to evolve new proteins and Winter used the method to evolve antibodies, which are disease-fighting proteins in the blood.

The first pharmaceutical based on Winter’s work was approved for use in 2002 and is employed to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases, the academy said. The chemical name of the drug is adalimumab, which has several trade named including Humira, one of the top-selling drugs in the world.

Smith, speaking to The Associated Press after learning about this Nobel win, credited others for the work that led to his breakthrough.

“Very few research breakthroughs are novel. Virtually all of them build on what went on before. It’s happenstance. That was certainly the case with my work,” he said Wednesday. “Mine was an idea in a line of research that built very naturally on the lines of research that went before.”

Smith said he learned of the prize in a pre-dawn phone call from Stockholm.

“It’s a standard joke that someone with a Swedish accent calls and says ‘You won!’ But there was so much static on the line, I knew it wasn’t any of my friends,” he said.

American Chemical Society president Peter Dorhout praised the Nobel winners, saying “the laureates have used chemistry to accelerate the evolution of natural biological molecules that act as the critical machinery for living organisms.

“The breakthroughs from these researchers enable that to occur thousands of times faster than nature to improve medicines, fuels and other products,” he said.

Experts said the developments for which the winners won the 2018 prize can be more ecological than many other chemical processes.

Enzymes “are what all we organisms use to make our chemicals. So if you can harness enzymes for your own purposes, this is often more environmentally friendly than using heavy metals or toxic substances to make your chemicals,” said Johan Aqvist, a member of the Nobel Committee for Chemistry.

In other Nobel prizes this year, the medicine prize went Monday to James Allison of the University of Texas M.D. Anderson Cancer Center and Tasuku Honjo of Kyoto University, who learned how to release the brakes that cancer can put on the immune system, discoveries that helped cancer doctors fight many advanced-stage tumors and save an “untold” numbers of lives.

Scientists from the United States, Canada and France shared the physics prize Tuesday for revolutionizing the use of lasers in research.

Arthur Ashkin became the oldest Nobel Prize laureate at 96, while Donna Strickland of the University of Waterloo in Canada became only the third woman to win a physics Nobel. Strickland had worked with the third winner, Frenchman Gerard Mourou of the Ecole Polytechnique and the University of Michigan.

The winner of the Nobel Peace Prize is to be announced Friday. The Nobel Memorial Prize in Economic Sciences, honouring Alfred Nobel, the man who endowed the five Nobel Prizes, will be revealed on Monday.

No Nobel literature prize will be awarded this year due to a sex abuse scandal at the Swedish Academy, which choses the winner. The academy plans to announce both the 2018 and the 2019 winner next year — although the head of the Nobel Foundation has said the body must fix its tarnished reputation first.

The man at the centre of the Swedish Academy scandal, Jean-Claude Arnault, a major cultural figure in Sweden, was sentenced Monday to two years in prison for rape.

___

Heintz reported from Moscow. Malcolm Ritter and Chris Chester in New York contributed to this story.

Jim Heintz And David Keyton, The Associated Press






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Trump Admin Establishing Council To Make Buildings Beautiful Again

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From the Daily Caller News Foundation

By Jason Hopkins

The Trump administration is creating a first-of-its-kind task force aimed at ushering in a new “Golden Age” of beautiful infrastructure across the U.S.

The Department of Transportation (DOT) will announce the establishment of the Beautifying Transportation Infrastructure Council (BTIC) on Thursday, the Daily Caller News Foundation exclusively learned. The BTIC seeks to advise Transportation Secretary Sean Duffy on design and policy ideas for key infrastructure projects, including highways, bridges and transit hubs.

“What happened to our country’s proud tradition of building great, big, beautiful things?” Duffy said in a statement shared with the DCNF. “It’s time the design for America’s latest infrastructure projects reflects our nation’s strength, pride, and promise.”

“We’re engaging the best and brightest minds in architectural design and engineering to make beautiful structures that move you and bring about a new Golden Age of Transportation,” Duffy continued.

Mini scoop – here is the DOT’s rollout of its Beautifying Transportation Infrastructure Council, which will be tasked with making our buildings beautiful again. pic.twitter.com/9iV2xSxdJM

— Jason Hopkins (@jasonhopkinsdc) October 23, 2025

The DOT is encouraging nominations of the country’s best architects, urban planners, artists and others to serve on the council, according to the department. While ensuring that efficiency and safety remain a top priority, the BTIC will provide guidance on projects that “enhance” public areas and develop aesthetic performance metrics.

The new council aligns with an executive order signed by President Donald Trump in August 2025 regarding infrastructure. The “Making Federal Architecture Beautiful Again” order calls for federal public buildings in the country to “respect regional architectural heritage” and aims to prevent federal construction projects from using modernist and brutalist architecture styles, instead returning to a classical style.

“The Founders, in line with great societies before them, attached great importance to Federal civic architecture,” Trump’s order stated. “They wanted America’s public buildings to inspire the American people and encourage civic virtue.”

“President George Washington and Secretary of State Thomas Jefferson consciously modeled the most important buildings in Washington, D.C., on the classical architecture of ancient Athens and Rome,” the order continued. “Because of their proven ability to meet these requirements, classical and traditional architecture are preferred modes of architectural design.”

The DOT invested millions in major infrastructure projects since Trump’s return to the White House. Duffy announced in August a $43 million transformation initiative of the New York Penn Station in New York City and in September unveiledmajor progress in the rehabilitation and modernization of Washington Union Station in Washington, D.C.

The BTIC will comprise up to 11 members who will serve two-year terms, with the chance to be reappointed, according to the DOT. The task force will meet biannually. The deadline for nominations will end Nov. 21.

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New report warns WHO health rules erode Canada’s democracy and Charter rights

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Justice Centre for Constitutional Freedoms

The Justice Centre for Constitutional Freedoms has released a new report titled Canada’s Surrender of Sovereignty: New WHO health regulations undermine Canadian democracy and Charter freedoms. Authored by Nigel Hannaford, a veteran journalist and researcher, the report warns that Canada’s acceptance of the World Health Organization’s (WHO) revised International Health Regulations (IHR) represents a serious erosion of national independence and democratic accountability.

The IHR amendments, which took effect on September 19, 2025, authorize the WHO Director-General to declare global “health emergencies” that could require Canada to follow directives from bureaucrats in Geneva, bypassing the House of Commons and the will of Canadian voters.

The WHO regards these regulations as “binding,” despite having no ability or legal authority to impose such regulations. Even so, Canada is opting to accept the regulations as binding.

By accepting the WHO’s revised IHR, the report explains, Canada has relinquished its own control over future health crises and instead has agreed to let the WHO determine when a “pandemic emergency” exists and what Canada must do to respond to it, after which Canada must report back to the WHO.

In fact, under these International Health Regulations, the WHO could demand countries like Canada impose stringent freedom-violating health policies, such as lockdowns, vaccine mandates, or travel restrictions without debate, evidence review, or public accountability, the report explains.

Once the WHO declares a “Pandemic Emergency,” member states are obligated to implement such emergency measures “without delay” for a minimum of three months.

Importantly, following these WHO directives would undermine government accountability as politicians may hide behind international “commitments” to justify their actions as “simply following international rules,” the report warns.

Canada should instead withdraw from the revised IHR, following the example of countries like Germany, Austria, Italy, Czech Republic, and the United States. The report recommends continued international cooperation without surrendering control over domestic health policies.

Constitutional lawyer Allison Pejovic said, “[b]y treating WHO edicts as binding, the federal government has effectively placed Canadian sovereignty on loan to an unelected international body.”

“Such directives, if enforced, would likely violate Canadians’ Charter rights and freedoms,” she added.

Mr. Hannaford agreed, saying, “Canada’s health policies must be made in Canada. No free and democratic nation should outsource its emergency powers to unelected bureaucrats in Geneva.”

The Justice Centre urges Canadians to contact their Members of Parliament and demand they support withdrawing from the revised IHR to restore Canadian sovereignty and reject blind compliance with WHO directives.

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