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3 win chemistry Nobel; findings led to bestselling drug

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STOCKHOLM — Three researchers who “harnessed the power of evolution” to produce enzymes and antibodies that have led to a new bestselling drug and biofuels won the Nobel Prize in chemistry on Wednesday.

Frances Arnold of the California Institute of Technology was awarded half of the 9-million-kronor ($1.01 million) prize, while the other half will be shared by George Smith of the University of Missouri and Gregory Winter of the MRC molecular biology lab in Cambridge, England.

The Royal Swedish Academy of Sciences, which chose the winners, said Arnold, 62, conducted the first directed evolution of enzymes, whose uses include “more environmentally friendly manufacturing of chemical substances such as pharmaceuticals and the production of renewable fuels.”

Smith, 77, developed a method to evolve new proteins and Winter used the method to evolve antibodies, which are disease-fighting proteins in the blood.

The first pharmaceutical based on Winter’s work was approved for use in 2002 and is employed to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases, the academy said. The chemical name of the drug is adalimumab, which has several trade named including Humira, one of the top-selling drugs in the world.

Smith, speaking to The Associated Press after learning about this Nobel win, credited others for the work that led to his breakthrough.

“Very few research breakthroughs are novel. Virtually all of them build on what went on before. It’s happenstance. That was certainly the case with my work,” he said Wednesday. “Mine was an idea in a line of research that built very naturally on the lines of research that went before.”

Smith said he learned of the prize in a pre-dawn phone call from Stockholm.

“It’s a standard joke that someone with a Swedish accent calls and says ‘You won!’ But there was so much static on the line, I knew it wasn’t any of my friends,” he said.

American Chemical Society president Peter Dorhout praised the Nobel winners, saying “the laureates have used chemistry to accelerate the evolution of natural biological molecules that act as the critical machinery for living organisms.

“The breakthroughs from these researchers enable that to occur thousands of times faster than nature to improve medicines, fuels and other products,” he said.

Experts said the developments for which the winners won the 2018 prize can be more ecological than many other chemical processes.

Enzymes “are what all we organisms use to make our chemicals. So if you can harness enzymes for your own purposes, this is often more environmentally friendly than using heavy metals or toxic substances to make your chemicals,” said Johan Aqvist, a member of the Nobel Committee for Chemistry.

In other Nobel prizes this year, the medicine prize went Monday to James Allison of the University of Texas M.D. Anderson Cancer Center and Tasuku Honjo of Kyoto University, who learned how to release the brakes that cancer can put on the immune system, discoveries that helped cancer doctors fight many advanced-stage tumors and save an “untold” numbers of lives.

Scientists from the United States, Canada and France shared the physics prize Tuesday for revolutionizing the use of lasers in research.

Arthur Ashkin became the oldest Nobel Prize laureate at 96, while Donna Strickland of the University of Waterloo in Canada became only the third woman to win a physics Nobel. Strickland had worked with the third winner, Frenchman Gerard Mourou of the Ecole Polytechnique and the University of Michigan.

The winner of the Nobel Peace Prize is to be announced Friday. The Nobel Memorial Prize in Economic Sciences, honouring Alfred Nobel, the man who endowed the five Nobel Prizes, will be revealed on Monday.

No Nobel literature prize will be awarded this year due to a sex abuse scandal at the Swedish Academy, which choses the winner. The academy plans to announce both the 2018 and the 2019 winner next year — although the head of the Nobel Foundation has said the body must fix its tarnished reputation first.

The man at the centre of the Swedish Academy scandal, Jean-Claude Arnault, a major cultural figure in Sweden, was sentenced Monday to two years in prison for rape.

___

Heintz reported from Moscow. Malcolm Ritter and Chris Chester in New York contributed to this story.

Jim Heintz And David Keyton, The Associated Press






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Mortgaging Canada’s energy future — the hidden costs of the Carney-Smith pipeline deal

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By Dan McTeague

Much of the commentary on the Carney-Smith pipeline Memorandum of Understanding (MOU) has focused on the question of whether or not the proposed pipeline will ever get built.

That’s an important topic, and one that deserves to be examined — whether, as John Robson, of the indispensable Climate Discussion Nexus, predicted, “opposition from the government of British Columbia and aboriginal groups, and the skittishness of the oil industry about investing in a major project in Canada, will kill [the pipeline] dead.”

But I’m going to ask a different question: Would it even be worth building this pipeline on the terms Ottawa is forcing on Alberta? If you squint, the MOU might look like a victory on paper. Ottawa suspends the oil and gas emissions cap, proposes an exemption from the West Coast tanker ban, and lays the groundwork for the construction of one (though only one) million barrels per day pipeline to tidewater.

But in return, Alberta must agree to jack its industrial carbon tax up from $95 to $130 per tonne at a minimum, while committing to tens of billions in carbon capture, utilization, and storage (CCUS) spending, including the $16.5 billion Pathways Alliance megaproject.

Here’s the part none of the project’s boosters seem to want to mention: those concessions will make the production of Canadian hydrocarbon energy significantly more expensive.

As economist Jack Mintz has explained, the industrial carbon tax hike alone adds more than $5 USD per barrel of Canadian crude to marginal production costs — the costs that matter when companies decide whether to invest in new production. Layer on the CCUS requirements and you get another $1.20–$3 per barrel for mining projects and $3.60–$4.80 for steam-assisted operations.

While roughly 62% of the capital cost of carbon capture is to be covered by taxpayers — another problem with the agreement, I might add — the remainder is covered by the industry, and thus, eventually, consumers.

Total damage: somewhere between $6.40 and $10 US per barrel. Perhaps more.

“Ultimately,” the Fraser Institute explains, “this will widen the competitiveness gap between Alberta and many other jurisdictions, such as the United States,” that don’t hamstring their energy producers in this way. Producers in Texas and Oklahoma, not to mention Saudi Arabia, Venezuela, or Russia, aren’t paying a dime in equivalent carbon taxes or mandatory CCUS bills. They’re not so masochistic.

American refiners won’t pay a “low-carbon premium” for Canadian crude. They’ll just buy cheaper oil or ramp up their own production.

In short, a shiny new pipe is worthless if the extra cost makes barrels of our oil so expensive that no one will want them.

And that doesn’t even touch on the problem for the domestic market, where the higher production cost will be passed onto Canadian consumers in the form of higher gas and diesel prices, home heating costs, and an elevated cost of everyday goods, like groceries.

Either way, Canadians lose.

So, concludes Mintz, “The big problem for a new oil pipeline isn’t getting BC or First Nation acceptance. Rather, it’s smothering the industry’s competitiveness by layering on carbon pricing and decarbonization costs that most competing countries don’t charge.” Meanwhile, lurking underneath this whole discussion is the MOU’s ultimate Achilles’ heel: net-zero.

The MOU proudly declares that “Canada and Alberta remain committed to achieving Net-Zero greenhouse gas emissions by 2050.” As Vaclav Smil documented in a recent study of Net-Zero, global fossil-fuel use has risen 55% since the 1997 Kyoto agreement, despite trillions spent on subsidies and regulations. Fossil fuels still supply 82% of the world’s energy.

With these numbers in mind, the idea that Canada can unilaterally decarbonize its largest export industry in 25 years is delusional.

This deal doesn’t secure Canada’s energy future. It mortgages it. We are trading market access for self-inflicted costs that will shrink production, scare off capital, and cut into the profitability of any potential pipeline. Affordable energy, good jobs, and national prosperity shouldn’t require surrendering to net-zero fantasy.If Ottawa were serious about making Canada an energy superpower, it would scrap the anti-resource laws outright, kill the carbon taxes, and let our world-class oil and gas compete on merit. Instead, we’ve been handed a backroom MOU which, for the cost of one pipeline — if that! — guarantees higher costs today and smothers the industry that is the backbone of the Canadian economy.

This MOU isn’t salvation. It’s a prescription for Canadian decline.

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Cost of bureaucracy balloons 80 per cent in 10 years: Public Accounts

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By Franco Terrazzano 

The cost of the bureaucracy increased by $6 billion last year, according to newly released numbers in Public Accounts disclosures. The Canadian Taxpayers Federation is calling on Prime Minister Mark Carney to immediately shrink the bureaucracy.

“The Public Accounts show the cost of the federal bureaucracy is out of control,” said Franco Terrazzano, CTF Federal Director. “Tinkering around the edges won’t cut it, Carney needs to take urgent action to shrink the bloated federal bureaucracy.”

The federal bureaucracy cost taxpayers $71.4 billion in 2024-25, according to the Public Accounts. The cost of the federal bureaucracy increased by $6 billion, or more than nine per cent, over the last year.

The federal bureaucracy cost taxpayers $39.6 billion in 2015-16, according to the Public Accounts. That means the cost of the federal bureaucracy increased 80 per cent over the last 10 years. The government added 99,000 extra bureaucrats between 2015-16 and 2024-25.

Half of Canadians say federal services have gotten worse since 2016, despite the massive increase in the federal bureaucracy, according to a Leger poll.

Not only has the size of the bureaucracy increased, the cost of consultants, contractors and outsourcing has increased as well. The government spent $23.1 billion on “professional and special services” last year, according to the Public Accounts. That’s an 11 per cent increase over the previous year. The government’s spending on professional and special services more than doubled since 2015-16.

“Taxpayers should not be paying way more for in-house government bureaucrats and way more for outside help,” Terrazzano said. “Mere promises to find minor savings in the federal bureaucracy won’t fix Canada’s finances.

“Taxpayers need Carney to take urgent action and significantly cut the number of bureaucrats now.”

Table: Cost of bureaucracy and professional and special services, Public Accounts

Year Bureaucracy Professional and special services

2024-25

$71,369,677,000

$23,145,218,000

2023-24

$65,326,643,000

$20,771,477,000

2022-23

$56,467,851,000

$18,591,373,000

2021-22

$60,676,243,000

$17,511,078,000

2020-21

$52,984,272,000

$14,720,455,000

2019-20

$46,349,166,000

$13,334,341,000

2018-19

$46,131,628,000

$12,940,395,000

2017-18

$45,262,821,000

$12,950,619,000

2016-17

$38,909,594,000

$11,910,257,000

2015-16

$39,616,656,000

$11,082,974,000

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