SEATTLE — Paul G. Allen, who co-founded Microsoft with his childhood friend Bill Gates before becoming a billionaire philanthropist, technology investor and owner of several professional sports teams, has died. He was 65.

He died Monday in Seattle, according to his company Vulcan Inc. Earlier this month Allen announced that the non-Hodgkin’s lymphoma that he was treated for in 2009 had returned and he planned to fight it aggressively.

Gates said he was heartbroken about the loss of one of his “oldest and dearest friends.”

“Personal computing would not have existed without him,” Gates said in a statement, adding that Allen’s “second act” as a philanthropist was “focused on improving people’s lives and strengthening communities in Seattle and around the world.”

Allen and Gates met while attending a private school in north Seattle. The two friends would later drop out of college to pursue the future they envisioned: A world with a computer in every home.

Gates so strongly believed in their dream that he left Harvard University in his junior year to devote himself full-time to his and Allen’s startup, which Allen dubbed Micro-Soft, short for microprocessors and software. Allen spent two years at Washington State University before dropping out as well.

They founded the company in Albuquerque, New Mexico, and their first product was a computer language for the Altair hobby-kit personal computer, giving hobbyists a basic way to program and operate the machine.

After Gates and Allen found some success selling their programming language, MS-Basic, the Seattle natives moved their business in 1979 to Bellevue, Washington, not far from its eventual home in Redmond.

Microsoft’s big break came in 1980, when IBM Corp. decided to move into personal computers and asked Microsoft to provide the operating system.

Gates and company didn’t invent the operating system. To meet IBM’s needs, they spent $50,000 to buy one known as QDOS from another programmer, Tim Paterson. Eventually the product refined by Microsoft — and renamed DOS, for Disk Operating System — became the core of IBM PCs and their clones, catapulting Microsoft into its dominant position in the PC industry.

The first versions of two classic Microsoft products, Microsoft Word and the Windows operating system, were released in 1983. By 1991, Microsoft’s operating systems were used by 93 per cent of the world’s personal computers.

The Windows operating system is now used on most of the world’s desktop computers, and Word is the cornerstone of the company’s prevalent Office products.

Allen, however, departed the company just eight years after its founding in 1975. He served as Microsoft’s executive vice-president of research and new product development until 1983, when he resigned after being diagnosed with cancer.

“To be 30 years old and have that kind of shock — to face your mortality — really makes you feel like you should do some of the things that you haven’t done yet,” Allen said in a 2000 book, “Inside Out: Microsoft in Our Own Words.”

Two weeks ago, Allen announced that a different cancer — non-Hodgkin’s lymphoma, which he was treated for in 2009 — had returned.

Over the course of several decades, Allen gave more than $2 billion to a wide range of interests, including ocean health, homelessness and advancing scientific research. With his sister Jody Allen in 1986, Paul Allen founded Vulcan, the investment firm that oversees his business and philanthropic efforts.

“Millions of people were touched by his generosity, his persistence in pursuit of a better world, and his drive to accomplish as much as he could with the time and resources at his disposal,” Vulcan CEO Bill Hilf said in a statement.

Allen was on the list of America’s wealthiest people who pledged to give away the bulk of their fortunes to charity. “Those fortunate to achieve great wealth should put it to work for the good of humanity,” he said.

His influence is firmly imprinted on the cultural landscape of Seattle and the Pacific Northwest, from the bright metallic Museum of Pop Culture designed by architect Frank Gehry to the computer science centre at the University of Washington that bears his name.

He founded the Allen Institute for Brain Science and the aerospace firm Stratolaunch, which has built a colossal airplane designed to launch satellites into orbit. He has also backed research into nuclear-fusion power.

“My brother was a remarkable individual on every level,” his sister Jody Allen said in a statement. “Paul’s family and friends were blessed to experience his wit, warmth, his generosity and deep concern.”

Allen also funded maverick aerospace designer Burt Rutan’s SpaceShipOne, which in 2004 became the first privately developed manned spacecraft to reach space.

The SpaceShipOne technology was licensed by Sir Richard Branson for Virgin Galactic, which is testing a successor design to carry tourists on brief hops into lower regions of space.

Branson tweeted Monday: “So sad to hear about the passing of Paul Allen. Among many other things he was a pioneer of commercial space travel. We shared a belief that by exploring space in new ways we can improve life on Earth.”

Allen was also an avid sports fan and used some of his fortune to buy several professional teams.

In 1988 at 35, he bought the Portland Trail Blazers and told The Associated Press that “for a true fan of the game, this is a dream come true.”

He also was a part owner of the Seattle Sounders FC, a major league soccer team, and bought the Seattle Seahawks. Allen could sometimes be seen at games or chatting in the locker room with players.

When he released his 2011 memoir, “Idea Man,” he allowed 60 Minutes inside his home on Lake Washington, across the water from Seattle, revealing collections that ranged from the guitar Jimi Hendrix played at Woodstock to vintage war planes and a 300-foot yacht with its own submarine.

Phuong Le, The Associated Press