New frontiers in prostate cancer treatment with Actinium-225

Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.

At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.

Principle of the method

Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.

Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.

In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.

Advantages and disadvantages of Actinium-225

Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).

Advantages of Actinium-225 over Lutetium-177:

● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy

However, it is worth considering the disadvantages of this method:

● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth

Who is a candidate for Actinium therapy

Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:

● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses

In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.

If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.

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Historic Return: NHL Confirms Player Participation in 2026 Winter Olympics

Published on November 16, 2025

Duane Rolheiser

The NHL has officially confirmed the inclusion of its players in the 2026 Winter Olympics in Milan-Cortina, Italy, following a 12-year absence that left the fans craving the excitement of the real best-on-best international hockey. The announcement is a historical event, as it goes back to the Olympic arena where the hockey powerhouse nations of the world will eventually be faced with their complete NHL prowess.

The ruling has not only shaken the hockey fraternity but also the sports fraternity at large, as it has generated early predictions, betting debates, and revived rivalries. Also, such large websites as GGBet, where many fans place their bets, have also been on the lookout, offering odds and analysis on which country will win gold.

A Long-Awaited Comeback

Since the 2014 Olympics in Sochi, NHL players have not been given the chance to play in the Olympics. The spectators have since witnessed world championships that, even though competitive, did not have the superstar appeal of Olympic hockey. This decision of the league in selecting the players to Milan-Cortina is a recreation of the desires of the NHL and the international arena to become one again.

The 2026 tournament will be the one offering the excitement, talent, and passion that will be fitting among NHL players. These legends, such as Sidney Crosby, Connor McDavid, Auston Matthews, and Leon Draisaitl, could play with young players like Jack Hughes and Tim Stützle – that sort of experience and youth.

The Tournament Breakdown

The event in hockey will take place between 11 and 22 February 2026, and the team count will be 12, which will be divided into three groups:

● A: Canada, Switzerland, Czechia, France.
● B: Italy, Finland, Sweden, Slovakia.
● C: Latvia, Denmark, the US, Germany.

The teams will be playing three pre-elimination games followed by play-off, which will lead to the final match, and a gold medal will be given on February 22.

Slovakia is going to play against Finland, and Sweden against Italy. Team USA starts playing on February 12, and Team Canada plays against Czechia. The matches would all be at either the Santagiulia Ice Hockey Arena or the Rho Ice Hockey Arena, both in Milan.

Why This Moment Matters

It is not only entertainment but a legacy that the NHL has gone back to the Olympics. To the league, it reestablishes itself as the world body in professional hockey. To players, it makes their lifelong dream of playing in the national team a reality in the biggest sporting arena. And to fans, it revives the magic that made such moments as Crosby scoring his Golden Goal in Vancouver 2010 unforgettable.

Nevertheless, beyond the ice, such a move will make the NHL more global and strengthen the new generation of sportsmen. The Games of 2026 are expected to achieve a huge global following, whereby fans in North America, Europe, and other continents will be reached.

Looking Ahead

As the opening of February 2026 approaches, the teams are plotting, investigating, and preparing to contest a tournament that numerous people are calling the most competitive Olympic hockey tournament to date. The already existing dream is Canada vs. USA, Finland vs. Sweden, and national pride will clash against the NHL-type talent.

Final Thoughts

It is not a sports story, but a cultural phenomenon because NHL players are returning to the 2026 Winter Olympics. It is an embodiment of unity, excellence, and the unadulterated affection of hockey. The fans all around the world are eagerly awaiting the days when the puck will drop in Milan and they will be watching a show that has been 12 years in the making.

The tournament will not be remembered for the successive gold medals, but rather for the first face-off to the final gold medal celebration. It can be either your country that wins; it could be just watching the magic, but in any case, one thing is certain: the Olympics are back, and the game has never been this alive.

Alberta

From Underdog to Top Broodmare

Published on October 31, 2025

Todayville

WATCH From Underdog to Top Broodmare (video)

Executive Producers Jeff Robillard (Horse Racing Alberta) and Mike Little (Shinelight Entertainment)

What began as an underdog story became a legacy of excellence. Crackers Hot Shot didn’t just race — she paved the way for future generations, and in doing so became one of the most influential producers the province has known.

The extraordinary journey of Crackers Hot Shot — once overlooked, now revered — stands as one of Alberta’s finest success stories in harness racing and breeding.

Born in humble circumstances and initially considered rough around the edges, Crackers Hot Shot overcame long odds to carve out a career that would forever impact the province’s racing industry. From a “wild, unhandled filly” to Alberta’s “Horse of the Year” in 2013, to producing foals who carry her spirit and fortitude into future generations.

Her influence ripples through Alberta’s racing and breeding landscape: from how young stock are prepared, to the aspirations of local breeders who now look to “the mare that did it” as proof that world-class talent can emerge from Alberta’s paddocks.

“Crackers Hot Shot, she had a tough start. She wasn’t much to look at when we first got her” — Rod Starkewski

“Crackers Hot Shot was left on her own – Carl Archibald heard us talking, he said ‘I’ll go get her – I live by there’. I think it took him 3 days to dig her out of the snow. She was completely wild – then we just started working on her. She really needed some humans to work with her – and get to know that people are not scary.” — Jackie Starkewski

“Crackers Hot Shot would be one of the top broodmares in Albeta percentage wise if nothing else. Her foals hit the track – they’re looking for the winners circle every time.” — Connie Kolthammer

Visit thehorses.com to learn more about Alberta’s Horse Racing industry.