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New frontiers in prostate cancer treatment with Actinium-225

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Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.

At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.

Principle of the method

Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.

Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.

In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.

Advantages and disadvantages of Actinium-225

Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).

Advantages of Actinium-225 over Lutetium-177:

● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy

However, it is worth considering the disadvantages of this method:

● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth

Who is a candidate for Actinium therapy

Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:

● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses

In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.

If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.

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Top Used Ford SUVs for Families and Adventurers

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Finding the perfect SUV that balances comfort, safety, and adventure-ready performance can be a challenge, but Ford’s lineup of used SUVs offers some of the best options available. Whether you need a spacious vehicle for your growing family or an all-terrain companion for weekend getaways, there’s a Ford SUV to match your lifestyle. Let’s explore the top choices that deliver reliability, versatility, and affordability.

What to Look for in a Used Ford SUV?

Before diving into specific models, it’s essential to know what features matter most when shopping for a used Ford SUV. Here are key factors to consider:

● Safety Features – Look for models equipped with Ford Co-Pilot360, which includes automatic emergency braking, blind-spot monitoring, and adaptive cruise control.
● Reliability and Maintenance Costs – Research common issues and ensure the SUV has a solid maintenance history.
● Fuel Efficiency – Choose a model that aligns with your commuting or road trip needs.
● Cargo and Passenger Space – Ensure the SUV has enough room for your family, gear, and pets.
● Off-Road Capability – If adventure is your goal, opt for models with all-wheel drive (AWD) or four-wheel drive (4WD).

If you’re ready to explore available options, check out https://stampedeauto.com/used-ford/ for a selection of quality used Ford SUVs.

1. Ford Escape – The Compact Family Favorite

The Ford Escape is a practical, fuel-efficient SUV perfect for small families and urban explorers. With a history of strong safety ratings and a spacious interior, it strikes a balance between convenience and performance.

Why Choose a Used Ford Escape?

● Fuel Efficiency – Older models with the 1.5L EcoBoost engine offer up to 30 MPG highway.
● User-Friendly Technology – Equipped with Ford SYNC infotainment and smartphone connectivity.
● Versatile Cargo Space – Fold-flat rear seats provide ample room for groceries, sports equipment, or luggage.
● Best Model Years to Buy – 2018-2021 models have modern safety features and improved fuel economy.

2. Ford Edge – The Perfect Mid-Size Balance

For those who want more space without stepping into full-size territory, the Ford Edge is an ideal midsize SUV. It offers a roomy two-row layout, strong engine options, and a smooth ride.

Why Choose a Used Ford Edge?

● Spacious Cabin – More rear legroom than many competitors.
● Powerful Engine Choices – Available 2.0L EcoBoost and 2.7L V6 for extra performance.
● Advanced Safety Features – Includes lane-keeping assist and pre-collision assist in newer models.
● Best Model Years to Buy – 2019-2022 models offer a modern design and strong reliability.

3. Ford Explorer – The Ultimate Family SUV

If you need three rows of seating without sacrificing performance, the Ford Explorer is a top contender. It’s an excellent SUV for large families and those who need extra passenger capacity.

Why Choose a Used Ford Explorer?

● Seating for Up to Seven – Third-row seats offer flexibility for larger families.
● Strong Towing Capacity – Can tow up to 5,000 lbs when properly equipped.
● Powerful Yet Efficient – The 2.3L EcoBoost engine delivers a balance of power and fuel savings.
● Best Model Years to Buy – 2017-2022 models feature advanced driver assistance and improved comfort.

4. Ford Expedition – The Full-Size Powerhouse

For those who need maximum space and towing capability, the Ford Expedition is a standout choice. It’s built for large families, cross-country road trips, and hauling heavy loads.

Why Choose a Used Ford Expedition?

● Room for Eight – A full-size SUV with unmatched passenger space.
● Towing King – Can tow up to 9,300 lbs, ideal for boats and trailers.
● High-Tech Features – SYNC 3 infotainment and multiple USB ports keep everyone connected.
● Best Model Years to Buy – 2018-2022 models have turbocharged efficiency and refined interiors.

5. Ford Bronco Sport – The Adventurer’s Compact Choice

For outdoor enthusiasts, the Ford Bronco Sport is a rugged compact SUV designed for off-road fun while still being a practical daily driver.

Why Choose a Used Ford Bronco Sport?

● Trail-Ready Performance – Standard AWD and off-road modes for different terrains.
● Compact Yet Spacious – Clever storage solutions for camping and gear.
● Turbocharged Engines – 1.5L and 2.0L EcoBoost options for strong performance.
● Best Model Years to Buy – 2021-2023 models provide the latest tech and rugged styling.

Before purchasing a used Ford Bronco Sport, be sure to check for any recalls. For example, certain Ford Bronco Sport and Maverick models have been recalled to fix faulty batteries. To learn more about this, visit Consumer Reports’ coverage on the recall.

Buying Tips: How to Get the Best Deal on a Used Ford SUV

● Certified Pre-Owned (CPO) Options – Ford’s CPO program includes extended warranties and inspections.
● Check Vehicle History Reports – Avoid SUVs with major accidents or unresolved recalls.
● Test Drive and Inspection – Always inspect brakes, transmission, and suspension.
● Compare Prices – Look at local dealerships and online marketplaces for the best deals.
● Negotiate Smartly – Research market value and be prepared to walk away if needed. It also helps to choose a used car dealer with transparent pricing and a solid reputation.

Conclusion

Choosing the right used Ford SUV depends on your specific needs. If you want fuel efficiency and city-friendly size, the Escape is a great choice. For those needing extra space and towing power, the Explorer or Expedition are top contenders. If adventure is a priority, the Bronco Sport
offers unbeatable off-road capability.

No matter which Ford SUV you choose, you’ll get a reliable vehicle that blends comfort, technology, and performance—without the high price tag of a new model. Start your search today and find the perfect used Ford SUV for your family or next adventure.

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Alberta Plans To Open iGaming Market After Ontario’s Success

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With plans to regulate its iGaming market, Alberta aims to deliver safer gaming experiences, greater variety for players, and stronger consumer protections.

Alberta is preparing to launch a regulated iGaming market, following Ontario’s successful model. By opening the industry to private operators, the province aims to increase competition, enhance consumer protections, and generate significant revenue. If implemented, this move could position Alberta as a key player in Canada’s evolving online gaming landscape.

The Alberta government has announced plans to open its iGaming market, following in the footsteps of Ontario’s regulated model. The move is expected to create a competitive online gaming environment by allowing private operators to enter the market, rather than keeping online gambling under the sole control of Alberta Gaming, Liquor and Cannabis (AGLC). This shift aligns with the province’s broader strategy to modernize its gaming industry, offering more choices for players while generating additional revenue for public services.

Key stakeholders in this expansion include AGLC, which will oversee regulatory compliance and licensing, and private gaming operators looking to secure a presence in the province. While specific details about licensing requirements and revenue-sharing structures are still being finalized, industry experts anticipate a framework similar to Ontario’s, where operators must meet strict guidelines to ensure consumer protection. Although no official launch date has been set, Alberta officials have indicated that the market could open within 2025, pending regulatory approvals and final policy decisions.

Learning from Ontario’s iGaming Model

Ontario’s transition to a regulated iGaming market in 2022 has been widely regarded as a success, providing a model for other provinces like Alberta to follow. By allowing private operators to enter the market under the oversight of iGaming Ontario (iGO), the province created a competitive and transparent industry that offers players a safer and more diverse gaming experience. The shift also helped curb unregulated offshore gambling by giving players legal, well-regulated alternatives.

Since its launch, the market has seen impressive growth. In its first year, the province generated over $1.4 billion in gaming revenue, making it one of the largest regulated online gaming markets in North America. The competitive landscape has attracted dozens of operators, contributing to job creation and economic development while ensuring a steady stream of tax revenue.

Apart from financial success, regulation has strengthened consumer protection through responsible gaming measures, operator accountability, and stringent licensing requirements. This model has boosted government revenue and set a precedent for how other Canadian provinces, including Alberta, can structure their own regulated iGaming markets.

 

Potential Challenges and Considerations

While Alberta’s plan to open its iGaming market presents significant opportunities, it also comes with challenges that must be carefully managed. One key hurdle is the regulatory framework, as the province must establish clear licensing requirements, tax structures, and operational guidelines to ensure a smooth transition. Policymakers will need to balance industry growth with responsible gaming practices, learning from Ontario’s experience to avoid potential pitfalls.

Responsible gaming will be another major focus, as increased accessibility to online gambling can raise concerns about addiction and player protection. AGLC will need to implement strict measures, including self-exclusion programs, deposit limits, and public awareness campaigns to promote safe gaming habits. Ensuring that operators comply with these measures will be critical to maintaining consumer trust.

Industry and Player Expectations

This move has sparked interest among gaming operators and industry experts. Many see this as a natural progression following Ontario’s success, with expectations that the province will attract major operators eager to expand into a newly regulated space. However, industry leaders will be watching closely to see how Alberta structures its licensing process and tax rates, which will play a key role in determining the market’s competitiveness.

While Alberta is following Ontario’s lead, its approach may differ in key areas. Ontario operates through iGaming Ontario, a regulatory body that oversees private operators, while Alberta may take a more direct role through AGLC. Additionally, given Alberta’s smaller population compared to Ontario, the province may focus on a more controlled rollout rather than opening the market all at once.

For players, the expansion could mean access to a wider range of online casinos, better game variety, including a larger selection of online slots and table games, and more competitive promotions. With private operators entering the scene, expect an increase in sign-up offers, loyalty programs, and exclusive bonuses designed to attract new customers. If executed effectively, Alberta’s iGaming market could create a more dynamic and player-friendly experience while maintaining strong consumer protections.

What Alberta’s iGaming Future Could Look Like

Alberta’s plan to open its iGaming market marks a significant shift toward a more competitive and regulated online gaming industry. By following Ontario’s successful model, the province aims to create a safer and more dynamic gaming environment while driving economic growth. With private operators expected to enter the market under AGLC’s oversight, players will likely benefit from greater choice and enhanced consumer protections.

If Alberta successfully implements this framework, it could set the stage for other provinces to follow, further shaping Canada’s evolving iGaming landscape. A well-regulated market not only boosts provincial revenue but also strengthens responsible gaming initiatives and keeps players within legal platforms. As the industry awaits further details, Alberta’s next steps will be crucial in determining whether it will become Canada’s next major online gaming hub.

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