Health
Canadian media might not be able to ignore new studies on harmful gender transitions for minors
From LifeSiteNews
When the UK National Health Service’s bombshell Cass Review condemning gender “transition” for minors was published, virtually the entire Canadian press engaged in a voluntary blackout.
Unless you were reading an alternative news source, an international news source, or the National Post, it was as if Cass Review — and its findings — had simply never existed. Many media outlets did not run a single story; the state-funded CBC ran precisely one, and it was a laughable hatchet job claiming that the massive study was “biased.” They did not interview a single person associated with the research.
The Canadian press has functioned for years as a propaganda arm for the transgender movement, even as the gender ideology house of cards topples in in the U.S. and the UK, where there have been genuinely robust debates informed by scientific evidence rather than ideology. Thus, I wonder how they will deal with new studies by Canadian researchers that reach many of the same conclusions.
As Sharon Kirkey of the National Post reported. “The evidence surrounding the use of puberty blockers and cross-sex hormones in children and teens identifying as transgender is of such low certainty it’s impossible to conclude whether the drugs help or harm, Canadian researchers are reporting.” The research was funded by the Society for Evidence-based Gender Medicine (SEGM) and McMaster University, considered to one of Canada’s top institutions of higher hearing, and published this week in the journal Archives of Disease in Childhood.
“There’s not enough reliable information,” said Chan Kulatunga-Moruzi, one of the authors of the two new reviews. “We really don’t have enough evidence to say that these procedures are beneficial. Few studies have looked at physical harm, so we have really no evidence of harm as well. There’s not a lot that we can say with certainty, based on the evidence.” (Here, I would note that there are now thousands of testimonies of detransitioners testifying to the harm that sex-change “treatments” have caused them, but this is a remarkable admission nonetheless.)
The researchers conclude that doctors should approach these “treatments” with extreme care, clearly communicating with parents and children and — notably — checking “whose values they are prioritizing” if they should decide to prescribe cross-sex hormones or puberty blockers. As Kirkey put it with devastating understatement: “Originally considered fully reversible, concerns are emerging about potential long-term or irreversible effects, the Canadian team wrote … Questions have been raised about the effects of fertility or what impact, if any, they might have on brain development.”
The researchers painstakingly went through the available evidence on both cross-sex hormones and puberty blockers (Kirkey irritatingly refers to them as “gender-affirming hormones”) for those up to 26 years old. To analyze the evidence, they “graded” it “using a scoring system co-developed by Dr. Gordon Guyatt, a celebrated McMaster University scientist who coined the phrase evidence-based medicine.” As Kirkey reported:
After screening 6,736 titles and abstracts involving puberty blockers, only 10 studies were included in their review. While children who received puberty blockers compared to those who don’t score higher on “global function” — quality of life, and general physical and psychological wellbeing — the evidence was of “very low certainty.” Very low, meaning researchers have “very little confidence in the effect estimate” and that the true effect “is likely to be substantially different from the estimate of effect.”
It gets worse. The research also debunked the perpetually asserted claim utilized by trans activists and their political allies to enforce their agenda: that these drugs are necessary to prevent depression and suicidal ideation. According to the researchers: “We are very uncertain about the causal effect of the (drugs) on depression. Most studies provided very low certainty of evidence about the outcomes of interest; thus, we cannot exclude the possibility of benefit or harm.” Again, despite the careful understatement, this is devastating: Thousands of children have been subjected to these treatments on the premise that they prevent harm and are harmless.
Indeed, the second review, which analyzed 24 studies, reached the similar conclusion of “very low confirmatory evidence of substantive change” not just in depression or health overall but even in gender dysphoria itself. As Kirkey noted: “Many studies suffered from missing data, small sample sizes, or lacked a comparison group.” The researchers concluded: “Since the current best evidence, including our systematic review and meta-analysis, is predominantly very low quality, clinicians must clearly communicate this evidence to patients and caregivers. Treatment decisions should consider the lack of moderate- and high-quality evidence, uncertainty about the effects of puberty blockers and patient’s values and preferences.”
Imagine for a moment that you are a teen or young person who started these treatments after having been told, with utter, aggressive confidence, by counselors, psychiatrists, and doctors that they were both harmless and necessary — that they could even save your life. Imagine being a parent who subjected your child to these treatments, convinced by “experts” that this was the best thing you could do to love your son or daughter. I have written these words too many times to count: This is a medical scandal of unprecedented proportions in this century, and those that perpetrated it must be held accountable.
Health
FDA warns ‘breast binder’ manufacturers to stop marketing to gender-confused girls
From LifeSiteNews
Dr. Marty Makary took aim at the transgender-medical-industrial complex that has exploded in recent years during a recent press conference.
Food and Drug Administration (FDA) commissioner Dr. Marty Makary has sternly warned companies manufacturing “breast binders” to cease marketing and supplying their product to gender-confused girls seeking to make their bodies appear masculine.
“Today the FDA is taking action,” said Makary in a press conference. “We are sending warning letters to 12 manufacturers and retailers for illegal marketing of breast binders for children, for the purposes of treating gender dysphoria.”
“Breast binders are a class one medical device with legitimate medical users, such as being used by women after breast cancer surgery,” but “these binders are not benign,” he cautioned. “Long-term usage has been associated with pain, compromised lung function, and even difficulty breast feeding later in life.”
“The warning letters will formally notify the companies of their significant regulatory violations and require prompt corrective action,” said the FDA head.
.@DrMakaryFDA: “Today the FDA is taking action. We are sending warning letters to 12 manufacturers and retailers for illegal marketing of breast binders for children, for the purposes of treating gender dysphoria.” pic.twitter.com/6JNAy36223
— HHS Rapid Response (@HHSResponse) December 18, 2025
The warning letter addressed to California manufacturer, GenderBender, notes that the company’s website states that “[c]hest binding is the practice of compressing breast mass into a more masculine shape, often done in the LGBTQ community for gender euphoria.”
“Your firm should take prompt action to address any violations identified in this letter. Failure to adequately address this matter may result in regulatory action being initiated by the FDA without further notice. These actions include, but are not limited to, seizure and injunction,” advised the FDA.
During his presentation, Makary took aim at the transgender-medical-industrial complex that has exploded in recent years.
“One of the most barbaric features of a society is the genital mutilation of its children,” observed Makary.
“Pushing transgender ideology in children is predatory, it’s wrong, and it needs to stop,” he declared.
“This ideology is a belief system that some teachers, some pediatricians, and others are selling to children without their parents knowing sometimes, or with a deliberate attempt to remove parents from the decision making,” Makary explained.
To witness society “putting kids on a path of chest binders, drugs, castration, mastectomies, and other procedures is a path that now many kids regret,” he lamented, as he pointed to Chloe Cole, who has reverted to her God-given femininity after undergoing so-called “gender-affirming” surgery as a teen.
Cole is a leading voice for young people who have “detransitioned” after having medically, surgically, and socially attempted to “transition” to a member of the opposite sex.
.@DrMakaryFDA: “Pushing transgender ideology in children is predatory, it's wrong, and it needs to stop.” pic.twitter.com/TXxWNEtNZk
— HHS Rapid Response (@HHSResponse) December 18, 2025
Health
All 12 Vaccinated vs. Unvaccinated Studies Found the Same Thing: Unvaccinated Children Are Far Healthier
I joined Del Bigtree in studio on The HighWire to discuss what the data now make unavoidable: the CDC’s 81-dose hyper-vaccination schedule is driving the modern epidemics of chronic disease and autism.
This was not a philosophical debate or a clash of opinions. We walked through irrefutable, peer-reviewed evidence showing that whenever vaccinated and unvaccinated children are compared directly, the unvaccinated group is far healthier—every single time.
Reanalyzing the Largest Vaccinated vs. Unvaccinated Birth-Cohort Study Ever Conducted
At the center of our discussion was our peer-reviewed reanalysis of the Henry Ford Health System vaccinated vs. unvaccinated birth-cohort study (Lamerato et al.)—the largest and most rigorous comparison of its kind ever conducted.
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The original authors relied heavily on Cox proportional hazards models, a time-adjusted approach that can soften absolute disease burden. Even so, nearly all chronic disease outcomes were higher in vaccinated children.
Our reanalysis used direct proportional comparisons, stripping away the smoothing and revealing the full magnitude of the signal.
- All 22 chronic disease categories favored the unvaccinated cohort when proportional disease burden was examined
- Cancer incidence was 54% higher in vaccinated children (0.0102 vs. 0.0066)
- When autism-associated conditions were grouped appropriately—including autism, ADHD, developmental delay, learning disability, speech disorder, neurologic impairment, seizures, and related diagnoses—the vaccinated cohort showed a 549% higher odds of autism-spectrum–associated clinical outcomes
The findings are internally consistent, biologically coherent, and concordant with every prior vaccinated vs. unvaccinated study, all of which show drastically poorer health outcomes among vaccinated children
The 12 Vaccinated vs. Unvaccinated Studies Regulators Ignore
In the McCullough Foundation Autism Report, we compiled all 12 vaccinated vs. unvaccinated pediatric studies currently available. These studies span different populations, countries, study designs, and data sources.
Every single one reports the same overall pattern. Across all 12 studies, unvaccinated children consistently exhibit substantially lower rates of chronic disease, including:
- Autism and other neurodevelopmental disorders
- ADHD, tics, learning and speech disorders
- Asthma, allergies, eczema, and autoimmune conditions
- Chronic ear infections, skin disorders, and gastrointestinal illness
This level of consistency across independent datasets is precisely what epidemiology looks for when assessing causality. It also explains why no federal agency has ever conducted—or endorsed—a fully vaccinated vs. fully unvaccinated safety study.
Flu Shot Failure
We also addressed the persistent failure of seasonal influenza vaccination.
A large Cleveland Clinic cohort study of 53,402 employees followed participants during the 2024–2025 respiratory viral season and found:
- 82.1% of employees were vaccinated against influenza
- Vaccinated individuals had a 27% higher adjusted risk of influenza compared with the unvaccinated state (HR 1.27; 95% CI 1.07–1.51; p = 0.007)
- This corresponded to a negative vaccine effectiveness of −26.9% (95% CI −55.0 to −6.6%), meaning vaccination was associated with increased—not reduced—risk of influenza
When vaccination exposure increases, chronic disease, neurodevelopmental disorders, and inflammatory illness increase with it. When children are unvaccinated, they are measurably healthier across virtually every outcome that matters.
The science needed to confront the chronic disease and autism epidemics already exists. What remains is the willingness to acknowledge it.
Epidemiologist and Foundation Administrator, McCullough Foundation
Support our mission: mcculloughfnd.org
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